【摘要】 选择保胎无忧散预处理试验小鼠,观察保胎无忧散对米非司酮(RU486)诱导流产作用的抑制效果。结果显示,使用RU486在孕7d,颈部注射后,试验小鼠的流产率达到了100%;应用中药方剂保胎无忧散能有效对抗RU486诱导的小鼠流产,试验中动物模型的流产率从100%下降到40%;组织学观察发现,RU486诱导流产小鼠子宫内膜出现明显损伤,而在中药方剂组,试验小鼠子宫得到了有效的保护。更多还原

【Abstract】 This study attempted to identify the potential immunomodulatory and anti-abortion effect of Baotai wuyousan on induced abortion by mifepristone(RU486).RU486 was given via subcutaneous injection to induce abortion in mice at day 7 of gestation after received an oral gavage formular medicines everyday and progesterone via peritoneal injection were observed as contral.The abortion rate of mouse given RU486 was 100%,and decreased to 40% dramatically as fed Baotai wuyousan,indicating its significant tocolysis effect on the abortion induced by RU486.更多还原