【摘要】 【目的】探讨多囊卵巢综合征(PCOS)患者血清内脂素(S visfatin)、卵泡液内脂素(FF visfatin)水平及其与PCOS的关系。【方法】选择同期因PCOS、输卵管等因素导致不孕行手术治疗的育龄女性,PCOS组20例,对照组20例。两组患者均于卵泡早期抽取静脉血检测性激素、血糖指标,测量身高、体质量、腰围、臀围以计算体质量指数BMI、腰臀比WHR;留取血清、卵泡液检测visfatin水平。【结果】(1)PCOS组S visfatin(20.03±3.07)ng/mL、FF visfatin(19.17±4.91)ng/mL水平分别高于对照组S visfatin(14.47±3.81)ng/mL、FF vifatin(13.20±4.12)ng/mL水平,差异均有统计学意义(P﹤0.001);(2)PCOS组S visfatin、FF vifatin水平呈正相关(r=0.67,P=0.004);对照组S visfatin、FF vifatin水平呈正相关(r=0.87,P<0.001);(3)研究对象总体多因素线性逐步回归分析结果显示,胰岛素抵抗指数(HOMA-IR)、WHR、LH/FSH可以解释S visfatin水平的80%;血清visfatin可以解释卵泡液visfatin水平的85%。【结论】PCOS患者存在高内脂素血症,其S visfatin、FF visfatin水平升高,且两者呈正相关;FF visfatin可能主要受到S visfatin的影响;HOMA-IR、WHR、LH/FSH与S visfatin呈正相关,提示visfatin可能参与了PCOS的发病机制。更多还原

【Abstract】 【Objective】 To explore the relationship between visfatin levels in serum,follicular fluid and its relationship with PCOS.【Methods】 Samples from PCOS group(n = 20) and control group(n = 20) were collected.All subjects were women of reproductive age.Sex hormone,glycometabolic indexes were detected in early follicular period.Height,weight,waist circumference,and hip circumference were collected to calculate BMI(body mass index) and WHR(waist to hip ratio).Serum and follicular fluid were preserved to detect visfatin levels.【Results】(1) S visfatin levels,FF visfatin levels in PCOS group were higher than that in the control group,respectively(P﹤0.001).(2) In the two groups,S visfatin levels positively correlated with FF visfatin levels(r = 0.67,P﹤0.05;r = 0.87,P﹤0.05).(3) In multiple regression analysis,S visfatin levels can be explained by HOMA-IR,WHR,and LH/FSH to some extent by 80%;FF visfatin levels can be explained by S visfatin levels to some extent by 85%.【Conclusion】 Hypervisfatinemia was evident in the women with PCOS.S visfatin levels and FF visfatin levels in PCOS group elevated,and they correlated positively.FF visfatin may be affected mainly by S visfatin.Visfatin may participate in the pathogenesis of PCOS.更多还原