【摘要】 目的:研究马齿苋不同提取物对D-半乳糖致衰老小鼠抗疲劳能力的影响,并探讨其机制。方法:取小鼠随机分为正常组、模型组、马齿苋正丁醇提取物(0.5,0.25 g.kg-1)组、马齿苋乙醇提取物(1,0.5 g.kg-1)组。除正常组sc生理盐水外,其他各组均sc D-半乳糖(1 g.kg-1)42 d制备衰老小鼠模型。用疲劳仪测定小鼠的抗疲劳能力,并测定脑组织丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性。结果:马齿苋正丁醇提取物(0.5 g.kg-1)和乙醇提取物(1 g.kg-1)组均可提高衰老小鼠的抗疲劳能力,马齿苋正丁醇提取物(0.5,0.25 g.kg-1)可降低脑组织MDA含量和提高SOD活性,马齿苋乙醇提取物(1 g.kg-1)可降低脑组织MDA含量。结论:马齿苋正丁醇提取物和乙醇提取物可提高衰老小鼠的抗疲劳能力,其机制可能与提高SOD活性降低MDA含量有关。马齿苋正丁醇提取物作用好于乙醇提取物。更多还原

【Abstract】 Objective: To study the anti-fatigue action of different extracts from Portulaca oleracea in senile mice by D-gal,and its mechanisms.Method: The mice were randomly divided into 4 groups: control group,model group,the n-butanol extracts from P.oleracea(0.5,0.25 g.kg-1) groups and the ethanol extracts from P.oleracea(1,0.5 g.kg-1) groups.The control group is given hypodermic injection of isotonic NaCl in the transverse part while the other groups successively administered by hypodermic injection of D-gal(1 g.kg-1).It is made a model of senile mice after 42 d continuation.To measure anti-fatigue performances with the Fatigue Instrument.To measure malondialdehyde(MDA) contents and superoxide dismutase(SOD) activity in brain tissue of senile mice.Result: The n-butanol extract from P.oleracea(0.5 g.kg-1) and the ethanol extract from P.oleracea(1 g.kg-1) could improve anti-fatigue performances.The n-butanol extracts from P.oleracea(0.5,0.25 g.kg-1) could decrease MDA contents and SOD activity in brain tissue.The ethanol extract from P.oleracea(1 g.kg-1) could decrease MDA contents n brain tissue.Conclusion: The n-butanol extract from P.oleracea and the ethanol extract from P.oleracea can improve anti-fatigue performances.Its mechanism maybe related by improve SOD activity and decrease MDA contents.The n-butanol extract from P.oleracea is better than the ethanol extract from P.oleracea.更多还原