【摘要】 目的:探讨肝苏颗粒对慢性乙型肝炎(CHB)患者白介素21(IL-21)的影响。方法:86例CHB患者随机分为观察组和对照组各43例。对照组采用派罗欣,180μg/次,1次/周,sc。观察组在此基础上加用肝苏颗粒,9 g/次,3次/d,口服。疗程24周。检测血清IL-21水平、乙肝病毒DNA(HBV-DNA)定量及肝功能。结果:治疗后两组HBV-DNA水平均较治疗前明显降低,观察组低于对照组(P<0.05);两组IL-21均较治疗前明显升高,观察组上升水平高于对照组(P<0.01);观察组治疗后门冬氨酸氨基转移酶(AST),丙氨酸转氨酶(ALT),谷酰转肽酶(GGT)及总胆红素(TBil)低于对照组(P<0.05,P<0.01),白蛋白(ALb)高于对照组(P<0.05)。结论:肝苏颗粒能升高CHB患者IL-21水平,具有抗乙肝病毒和保护肝功能的作用。更多还原

【Abstract】 Objective:To investigate the effect of Gansu granule on patients with chronic hepatitis B(CHB).Method:Eighty-six subjects were randomly divided into observation group and control group(n=43 each).Pegasys were given to the control group,180 μg each time,1 time each week.Based on the pegasys treatment,Gansu granule was added to the observation group,9 g,tid,all for 24 weeks.Interlukin-21(IL-21) level,hepatitis B virus-DNA(HBV-DNA) and lung function were quantified and measured.Result:The level of HBV-DNA in both groups after the treatment were lower than those before,the observation group were more lower than that in the control group(P<0.05).IL-21 level in both groups after the treatment were higher than before,the level in observation group was higher than that in the control group(P<0.01).Aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamete transpeptidase(GGT) and total bilirubin(Tbil) in the observation group after the treatment were lower than those in the control group(P<0.05,P<0.01),and albumin(Alb) of the observation group after the treatment were higher than that in the control group(P<0.05).Conclusion:Gansu granule can elevate IL-21 level for the patients with CHB.Gansu granule has anti-HBV function and could protect liver function.更多还原