【摘要】 目的:探讨痰热清注射液对急性肺损伤(ALI)肺功能的保护作用及对血管内皮因子的影响。方法:124例ALI患者随机分为观察组和对照组各62例,对照组采用常规急救治疗措施,包括静脉通道建立、循环支持、吸氧、抗生素应用及原发创伤处理等;观察组在对照组治疗基础上加用痰热清注射液20 mL加入5%葡萄糖注射液250 mL中静脉滴注,1次/d,疗程7 d;观察血气分析指标,全身炎性反应综合征(SIRS)及健康状况评分(APACHEⅡ评分),检测内皮素-1(ET-1),血管内皮生长因子(VEGF)及血管性假血友病因子(vWF)。结果:治疗3,7 d观察组氧分压(PO2),二氧化碳分压(PCO2)及氧合指数(PO2/FiO2)均较对照组上升更为显著(P<0.01);治疗后观察组SIRS及APACHEⅡ评分均低于对照组(P<0.05,P<0.01);治疗3,7 d观察组ET-1,VEGF,vWF水平均低于同期对照组(P<0.01);观察组发生机械通气例数及肺感染例数少于对照组(P<0.05)。结论:痰热清能降低血清ET-1,VEGF,vWF水平,减轻了血管内皮的损伤,减轻了肺水肿,保护了肺功能。更多还原

【Abstract】 Objective:To investigate the effect of Tanreqing injection in treatment of acute lung injury(ALI) on pulmonary function and protective effects on vascular endothelial growth factor effects.Method: One hundred and twenty-four cases of ALI were randomly divided into the observation group and the control group(n=62 each),the control group was received conventional emergency treatment,including venous channel establishment,circulatory support,oxygen supply,antibiotics and primary trauma treatment.On the basis of the measures in the control group,the observation group was given Tanreqing injection(20 mL in 5% glucose intravenous infusion of 250 mL) daily for 7 d.Blood gas indexes,systemic inflammatory response syndrome(SIRS) and Acute physiology and chronic health evaluation II(APACHE II) were investigated.Endothelin-1(ET-1),vascular endothelial growth factor(VEGF) and von willebrand factor(vWF) were determined.Result: After treatment for 3,7 days PO2,PCO2 and PO2/FiO2 in observation group were better than those in the control group significantly(P<0.01).After the treatment SIRS and APACHEⅡin observation group were lower than those in control group(P<0.05,P<0.01).After 3,7 days of treatment,ET-1,VEGF and vWF levels in the observation group were lower than those of the same period accordingly in the control group(P<0.01).Patients who needed mechanical ventilation and with pulmonary infection in observation group were less than that in control group(P<0.05).Conclusion: Tanreqing injection can decrease the serum ET-1,VEGF and vWF levels,reduce endothelial injury,reduce pulmonary edema,so it protects the lung function.更多还原