【摘要】 目的:通过Meta分析比较载脂蛋白B(ApoB)基因XbaI位点等位基因与基因型的分布频率,探讨ApoB基因XbaI多态性与胆石症的关系。方法:全面检索收集ApoB基因XbaI多态性与胆石症的有关研究文献。对各研究结果应用CMA2.0软件以Meta分析的方法进行数据合并,并评价合并值的发表偏倚。结果:符合纳入标准的相关文献13篇,其中胆石症组1 672例,对照组1 923例。Meta分析结果显示,在亚洲人群中,X+等位基因在胆石症组的分布频率明显高于对照组(OR=2.76,95%CI=2.12-3.59),而X-X-基因型在胆石症组的分布频率明显低于对照组(OR=0.35,95%CI=0.27-0.47)(均P<0.05)。发表性偏倚检验显示不存在发表偏倚,稳定性较好。结论:亚洲人群中胆石症的发生与ApoB基因XbaI多态性有关,等位基因X+可能是胆石症的危险因素,基因型X-X-可能是胆石症的保护因子。更多还原

【Abstract】 Objective:To investigate the relationship between XbaI polymorphism of apolipoprotein B(ApoB) gene and cholelithiasis through comparison of the allele and genotype distribution frequencies at XbaI site of ApoB gene by Meta-analysis.Methods:A literature search was performed regarding the relation of XbaI polymorphism of ApoB gene with gallstone.All trial data were combined and analyzed according to the Meta-analysis methodology using CMA2.0 software,and the publication bias of pooled studies was also assessed.Results:Thirteen related studies that met the inclusion criteria were selected,with 1 672 cases in gallstone group and 1 923 subjects in control group.The results of Meta-analyses showed that in Asian population,the frequency of X+ allele was significantly increased(OR=2.76,95% CI=2.12–3.59),but the frequency of X–/–genotype was significantly decreased in gallstone group compared with control group(OR=0.35,95% CI=0.27–0.47)(both P<0.05).Assessment found no evidence of publication bias that confirmed stability of this Meta-analysis.Conclusion:XbaI polymorphism of ApoB gene is associated with gallstone occurrence among Asians,in which the X+ allele is a risk factor and the g X–/–genotype is a protective factor.更多还原