【摘要】 目的研究乳腺癌组织中人类表皮生长因子受体-3(HER-3)的表达,并分析其表达与乳腺癌临床病理及预后的关系。方法收集2006年1～10月期间大连医科大学附属第二医院行手术、术前未经放化疗、术后行内分泌治疗且资料完整的女性乳腺癌患者139例。采用免疫组织化学法检测乳腺癌组织中HER-3的表达,并从病历资料中获得组织学分级、肿瘤大小、淋巴结转移、联系方式等资料,分析HER-3表达与乳腺癌患者的临床病理特征及预后的关系。结果①HER-3在乳腺癌组织中的表达阳性率为30.2%(42/139);②HER-3表达与患者年龄无关(r=0.030,P=0.721);③HER-3表达与肿瘤的大小(r=0.176,P=0.038)、淋巴结转移(r=0.205,P=0.016)及组织学分级(r=0.197,P=0.020)呈正相关,与5年生存率呈负相关(r=-0.254,P=0.003)。结论 HER-3的检测对乳腺癌的早诊断、早治疗、用药、预后有指导意义,并有可能指导新抗肿瘤药物的研发方向。更多还原

【Abstract】 Objective To study the expression of human epidermal growth factor receptor-3(HER-3)in breast cancer patients and analyze the relation between its expression and the clinical pathology of breast cancer.Methods The complete data of 139 female breast cancer patients underwent operation from January 2006 to October 2006 in this hospital were collected,who were without preoperative chemotherapy and radiation therapy,but with postoperative endocrine therapies.HER-3 expression in the breast cancer tissues was detected by immunohistochemistry.Information on histological grading,tumor diameter,lymph node metastasis,and telephone number were obtained from their medical records.The relation between indication and HER-3 expression was analyzed.Results ① The positive expression of HER-3 in the breast cancer tissues was 30.2%(42/139);② The expression of HER-3 was unrelated to the age of patient with breast cancer(r=0.030,P=0.721);③HER-3 expression was a positive related to the tumor diameter(r=0.176,P= 0.038),lymph node metastasis(r=0.205,P=0.016),or histological grading(r=0.197,P=0.020),which was a negative related to the five-year survival rate(r=-0.254,P=0.003).Conclusion Detection of HER-3 expression in breast cancer tissues might be a clinical significance for the early diagnosis/treatment,medication,and prognosis of the tumors as well as research and development of new drug.更多还原