【摘要】 目的:探讨近10年宁波地区初治结核病例抗结核药物耐药谱的发展变化特点,为有效防控结核病提供科学依据。方法:回顾分析宁波市1999年10月-2000年3月开展的耐药监测资料(设为Ⅰ组)及2009年7月-2009年12月开展的耐药监测资料(设为Ⅱ组),对两次耐药监测资料的耐药谱变化进行分析。结果:两次耐药监测资料的初治病例耐药谱变化比较分析显示:初治病例的耐单一药物率由8.9%升至17.5%(χ2=6.455,P<0.05),初治病例异烟肼(H)的耐药率由12.8%升至19.0%(χ2=3.907,P<0.05),初治病例链霉素(S)的耐药率由10.2%升至16.0%(χ2=3.970,P<0.05)。结论:宁波市初治病例肺结核耐药形势依然严峻,且耐药的发生更趋向于耐单一药物,今后须进一步加强耐药结核病的防治工作。更多还原

【Abstract】 Objective To explore the features of the change in the initial drug-resistant tuberculosis spectrum in the last decade in order to provide reference for TB control policy development in Ningbo.Methods We divided patients in different periods into two groups: In GroupⅠwere smear positive tuberculosis patients from October 1999 to March 2000,while in Group Ⅱ were smear positive tuberculosis patients from July 2009 to December 2009.Drug resistance data were analyzed retrospectively in these patients.ResultsThe DR-TB spectra of GroupⅠwere set as drug resistant units and compared with GroupⅡ.The rate of resistance to only one drug was increased from 8.9% to 17.5%(χ2=6.455,P<0.05),and dramatic increase could be found in some drug resistant units,including isoniazid(H) form 12.8% to 19.0%(χ2=3.907,P<0.05) and streptomycin(S) from 10.2% to 16.0%(χ2=3.970,P<0.05) in new smear positive case.Conclusion Initial drug-resistant tuberculosis epidemic is still serious in Ningbo,which tends to show single drug resistance.So it is necessary to improve the quality of DOTS.更多还原