【摘要】 目的:探讨抗环瓜氨酸肽(CCP)抗体和抗突变型瓜氨酸波形蛋白(MCV)抗体在早期类风湿关节炎(RA)患者体内水平和对其诊断价值。方法:采用酶联免疫吸附(ELISA)法,检测了87例早期RA患者(早期RA组)、40例中、晚期RA患者(中晚期RA组)、60例其他风湿病患者(对照组)和40例健康体检者(正常组)血清抗CCP抗体和抗MCV抗体的水平。结果:抗CCP抗体和抗MCV抗体,在早期RA组分别是(89.1±32.6)RU/ml和(92.5±36.4)U/ml,在中晚期RA组分别是(68.5±21.2)RU/ml和(70.3±25.0)U/ml,在对照组分别是(35.0±15.6)RU/ml和(30.2±12.3)U/ml,在正常组分别是(25.6±9.2)RU/ml和(18.5±8.4)U/ml。在早期RA组和在中晚期RA组,抗CCP抗体敏感度分别是67.8%和60.0%,特异性分别是89.6%和91.5%;抗MCV抗体的敏感度分别是78.1%和72.5%,特异性分别是94.2%和93.1%。结论:抗CCP抗体和抗MCV抗体对诊断早期RA具有良好的敏感性和特异性,两者可作为诊断早期RA的标记物,是诊断早期RA疾病的两个新指标。更多还原

【Abstract】 Objective: To investigate the diagnostic significance of anti-cyclic citrullinated peptide( CCP) antibodies and anti- mutant citrullinated vimentin( MCV) antibody in the diagnosis of the early stage of rheumatoid arthritis( RA). Methods: Using en- zyme-linked immunosorbent assay( ELISA) to detect the serum level of anti-CCP antibody and anti-MCV antibodies of 87 patients with RA( early RA group),40 patients in the middle and late stage of RA( middle and late stage RA group),60 patients with other rheu- matic diseases( control group) and 40 healthy subjects( normal group). Results: anti-CCP and anti-MCV antibodies in RA group were( 89. 1 ± 32. 6) RU / ml and( 92. 5 ± 36. 4) U / ml,the middle and late stage RA group were( 68. 5 ± 21. 2) RU / ml and( 70. 3 ± 25. 0) U / ml; in the control group were respectively( 35. 0 ± 15. 6) RU / ml and( 30. 2 ± 12. 3) U / ml,and the normal group were( 25. 6 ±9. 2) RU/ml and( 18. 5 ±8. 4) U/ml. In the RA group,the sensitivity of anti-CCP and anti-MCV antibodies were 67. 8% and 78. 1%,and specificity were 89. 6% and 94. 2% respectively. Conclusion: Anti-CCP and anti-MCV antibodies with good sensitivity and specificity for the diagnosis of the early stage of RA,both can be used as a new markers for diagnostic indicators of the early stage of RA disease.更多还原