【摘要】 目的探讨急性脑梗死(ACI)患者血清白介素-6(IL-6)及高敏C反应蛋白(hs-CRP)的含量水平与颈动脉斑块稳定性之间的关系。方法颈动脉超声法将106例经头部CT/MRI确诊的脑梗死患者分为无斑块组、斑块易损组和斑块稳定组,采用增强免疫比浊测量法检测患者血清中hs-CRP水平,以酶联免疫吸附法检测IL-6水平。结果 106例ACI患者中,83例检出斑块,检出率为78.3%。83例患者斑块多分布于左颈总动脉,其次为左颈动脉分叉处及右颈动脉分叉处;斑块易损组血清hs-CRP、IL-6浓度依次为(7.7±3.8)μg/ml、(97.6±20.4)pg/ml,显著高于斑块稳定组和无斑块组(P均<0.05)。结论血清hs-CRP、IL-6与动脉粥样硬化斑块的不稳定性关系密切,对评估病情与预后具有一定意义。更多还原

【Abstract】 Objective To investigate the relations between carotid atherosclerotic plaque stability and the serum concentration of interleukin-6(IL-6) and high sensitivity C-reactive protein(hs-CRP) in cases of acute cerebral infarction(ACI).Methods Totally 106 cases of ACI were divided into plaque vulnerability group,plaque stabilization group and no plaque group.The concentration of serum hs-CRP was detected by the immune enhance turbidimetry assay,and the levels of IL-6 were detected by enzyme-linked immunosorbent assay.Results Among 106 patients with ACI,83 patients with plaque were detected,positive rate was 78.3%.The serum concentration of hs-CRP and IL-6 was(7.7±3.8)mg/L and(97.6±20.4)pg/L in the plaque vulnerability group,significantly higher than the plaque stabilization group and the no plaque group(P<0.05).Conclusion The serum concentration of hs-CRP and IL-6 have closely relationship with artery atherosclerotic plaque instability,may be helpful to evaluate the condition and prognosis of the patients.更多还原