【摘要】 目的观察马来酸依那普利叶酸片对伴有同型半胱氨酸(Hcy)升高的高血压患者的疗效。方法选择230例伴有血浆同型半胱氨酸升高的原发性高血压患者,随机分为观察组(马来酸依那普利叶酸片10mg+0.8mg)和对照组(马来酸依那普利10mg),总观察治疗时间为36周。评价指标有:血压水平、血浆Hcy、尿白蛋白/肌酐比值(A/C)、颈动脉内膜厚度(IMT)。结果治疗前观察组与对照组在血压水平、Hcy、尿A/C、IMT差异无统计学意义。用药治疗36周后观察组与对照组在收缩压(SBP)与舒张压(DBP)水平的控制上差异有统计学意义(P<0.05);对于血浆Hcy的控制上观察组与对照组差异有统计学意义(P<0.01);在尿A/C比值水平的控制上观察组与对照组差异有统计学意义(P<0.01);对于IMT的控制上观察组与对照组差异有统计学意义(P<0.01)。结论马来酸依那普利叶酸片对于伴有血浆Hcy水平升高的高血压患者(H型高血压)的血压水平、血浆Hcy、尿A/C比值、IMT均有明显的改善,延缓了动脉粥样硬化的进展,保护了靶器官的功能。更多还原

【Abstract】 Objective To observe the therapeutic effect of malay acid enalaprilat folic acid tablets in hypertensive patients accompanied by elevated homocysteine(Hcy).Methods Total 230 patients with elevated plasma homocysteine in essential hypertension patients were randomly divided into experimental group(maleic acid enalaprilat folic acid tablets 10 mg + 0.8 mg) and control group(maleic acid enalaprilat 10 mg),all subjects were followed-up 36 weeks.Evaluation indexes included blood pressure,plasma homocysteine levels,the urinary albumin/creatinine ratio(A/C),carotid intimal thickness(IMT).Results Some indexes such as blood pressure,plasma homocysteine levels,the urinary albumin/creatinine ratio,carotid artery intima thickness in experimental group and control group before treatment were no statistical difference.On the control level of systolic blood pressure(SBP) and diastolic blood pressure(DBP) was statistically difference after 36 weeks drug treatment in experimental group and control group(P <0.05);the level of plasma homocysteine in experimental group was lower than control group(P <0.01).Urinary albumin/creatinine ratio of trial group and control group was statistically difference(P <0.05),and carotid artery intima thickness of experimental group and control group was also statistically difference(P <0.01).Conclusions For the hypertensive patients accompanied by elevated plasma homocysteine,maleic acid enalaprilat folic acid tablets can obvious decreased the level of blood pressure and blood plasma homocysteine,optimize the urinary albumin/creatinine ratio,improve the thickness of the carotid artery intima,delay the progression of atherosclerosis,protect the function of target organs.更多还原