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重度营养不良肺结核患者营养支持及疗效评价的临床观察

Nutrition supports and evaluation of their therapeutic effects on lung tuberculosis with sever malnutrition

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【作者】 吴晓光马丽萍高孟秋陈红梅刘荣梅谢莉李雪莲张立群

【Author】 Wu xiaoguang,Ma Liping,Gao Mengqiu,Chen Hongmei,Liu Rongmei,Xieli,Li Xuelian,Zhang Liqun(Beijing Chest Hospital,Capital Medical University,Beijing,101149 China)

【机构】 北京市结核病胸部肿瘤研究所首都医科大学附属北京胸科医院结核二科

【摘要】 目的观察重度营养不良肺结核患者营养支持的疗效。方法 62例肺结核患者进行NRS2002评估,且随机分为肠内营养组(EN组)、肠外营养组(PN组),两组患者均在营养支持前及营养支持2周后观察体质量变化百分比(IBW%)、血清白蛋白、血红蛋白、总淋巴细胞计数、结核中毒症状改善时间和住院时间及两组患者营养支持费用。结果两组病例治疗后IBW%、血清白蛋白、血红蛋白、淋巴细胞总数与治疗前相比差异有显著性(P<0.01);治疗后EN组IBW%及T-lymph较PN组有明显改善(P<0.05)。治疗后,NRS评估结果显示,两组营养状况均有好转,EN组患者营养状况改善明显好于PN组。EN组结核中毒症状改善时间和住院时间明显少于PN组(P<0.05),EN组营养支持费用显著低于PN组(P<0.01)。结论肠内营养及肠外营养均能改善重度营养不良肺结核患者的营养状态,肠内营养在临床疗效上优于肠外营养。

【Abstract】 Objective To give the nutritional supports and evaluation the therapeutic effects on lung tuberculosis with sever malnutrition.Method 62 patients received nutritional assessment by means of NRS2002 immediately after admitted into hospital and the patients who have more than 3 NRS score were divided into two groups randomly.Patients in PN group were given parenteral nutrition besides anti-tuberculosis therapy,while group EN was given enteral nutrition besides anti-tuberculosis therapy.The two groups were compared on IBW%、SAP、HB、TLC、clinic signs,time staying indepartment and fees for treatment.Result IBW% 、SAP 、HB 、TLC were both improved in two groups(P<0.01).The nutritional status and clinic signs were improved in EN group than that of PN group(P<0.05).The fees for treatment was decreased significantly in EN group than that of PN group(P<0.01).Conclusion Most of the patients with serious tuberculosis have malnutrition.Enteral nutrition combined with parenteral nutrition showed the best effect on these patients,so that we should encourage patients to take more food if possible.

【关键词】 结核营养评估营养支持
【Key words】 TuberculosisNutritional supportNutritional assessment
【基金】 “十二五”重大新药创制科技重大专项课题,“抗结核药物新药临床评价研究技术平台建设”(2012ZX09303002)
  • 【文献出处】 中国临床医生 ,Chinese Journal for Clinicians , 编辑部邮箱 ,2013年03期
  • 【分类号】R521
  • 【被引频次】26
  • 【下载频次】195
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