【摘要】 胰岛功能缺陷与胰岛素抵抗是2型糖尿病发病的两个关键因素。近年研究认为,氧化应激、炎症反应与脂肪内分泌相互作用,从而引起胰岛素抵抗和β细胞功能障碍。因此,对上述机制进行干预成为实验研究及临床治疗的一个热点。脂肪因子Apelin具有影响胰岛素敏感性、影响心血管功能、抗炎及抗氧化应激等作用。本文就Apelin与糖尿病、糖尿病血管并发症的关系展开综述。更多还原

【Abstract】 Islet B cell function defect and insulin resistance are two key factors for type 2 diabetes. Recent studies suggest that the interaction of oxidative stress, inflammation, and fat endocrine cause insulin resistance and beta cell dysfunction. Therefore, the intervention of above mechanism become a focus in the experimental study and clinical treatment. The fat factor--Apelin influences insulin sensitivity and cardiovascular function, anti-inflammatory and anti-oxidative stress, and so on. The relationship between Apelin and diabetes, vascular complications of diabetes were summarized in this review.更多还原