【摘要】 目的探讨不同年龄段发病的原发性干燥综合征(pSS)的临床特点。方法回顾性分析2005年7月至2012年1月在广西医科大学第一附属医院住院诊治的pSS患者227例,入选病例均符合2002年pSS国际分类(诊断)标准并排除合并其他结缔组织病。将入选病例按发病年龄不同分为青年组(≤40岁)和中老年组(>40岁),对两组pSS患者的临床资料进行统计分析。结果 (1)227例pSS患者中女205例(90.3%)、男22例(9.7%),男∶女为1∶9.32,青年组73例(32.2%),中老年组154例(67.8%),两组发病人数之比约为1∶2。(2)pSS常见首发症状居前三位者分别为口眼干、关节肿痛、猖獗龋齿。青年组与中老年组首发症状的比较,口眼干(17.8%vs.34.4%,χ2=6.624,P=0.010)、猖獗龋齿(4.1%vs.18.8%,χ2=8.863,P=0.003)、血小板减少性紫癜(13.7%vs.2.6%,χ2=8.715,P=0.003)均有统计学差异。(3)89.4%的pSS患者合并系统损害,主要累及血液系统(60.4%)、肾(30.4%)。(4)pSS系统中肺损害与临床实验指标的相关分析:肺受累与IgG、Glo升高关系密切(P<0.01)。结论 (1)青年组与中老年组发病人数比约为1∶2。(2)不同年龄pSS的首发症状不一。中老年组口眼干、猖獗龋齿较青年组明显增加,血小板减少性紫癜多见于青年组。(3)pSS合并系统受累的发生率高(89.4%)。中老年组出现肾小球肾炎、肾功能不全较多见,青年组发生血小板减少较中老年组明显增加。(4)pSS合并肺损伤与IgG、Glo升高关系密切。更多还原

【Abstract】 Objective To study the differences in clinical characteristics of primary Sj?gren’s syndrome(pSS) in a different onset age. Methods Two hundred and twenty seven patients from the first affiliated hospital of Guangxi Medical University between July 2005 and January 2012 were studied retrospectively. These patients were divided into the youth group(onset younger than 40) and the middle-old age group(onset older than 40). Results(1)The study consisted of 205(90.3%) female and 22(9.7%) male patients(female∶male 9.32∶1). 73(32.2%) patients of the disease onset occurred before the age of 40 years and 154(67.8%) occurred after the age of 40 years the ratio between the youth group(32.2%) and the middle-old age group(67.8%) was 1∶2.(2) The first three ones more common initial symptoms were dry mouth and dry eyes, decayed tooth and joint pain. in addition, the former two initial symptoms were often found in the middle-old age group patients, significantly higher than the youth group(P≤0.01), however lower in thrombocytopenic purpura(P=0.003).(3) Systemic involvement occurred in(89.4%) patients, including blood system involvement(60.4%), renal involvement(30.4%).(4) The main relevance factor of lung involvement were IgG and Glo(P<0.01). Conclusion(1) The rate of onset of the youth group and the middle-old age group in pSS was about 1∶2.(2) The typical initial symptom of the middle-old age group were dry mouth and dry eyes and decayed tooth, while thrombocytopenic purpura was more common in the youth group.(3)Systemic involvement occurred in 89.4% patients. Compared with the youth group, higher prevalence of interstitial lung disease, glomerulonephritis and renal insufficiency in the middle-old age group, while much lower incidence of thrombocytopenia than the youth group.(4)Lung involvement was closely related to the increase of IgG and Glo level in pSS.更多还原