【摘要】 目的对坦索罗辛联合体外冲击波碎石(ESWL)的治疗方法对上尿路结石(输尿管结石及肾结石)疗效评价分析。方法通过计算机检索PubMed、MEDLINE、万方数据库、CKNI数据库、维普数据库、Embase、Google数据库,收集相关外文随机对照试验,纳入符合研究并评价其方法学质量。使用统计学软件RevMan 4.2.2进行Meta分析。结果共纳入13个随机对照试验,7个在国外,6个在国内,共1322例患者。Meta分析结果表明:坦索罗辛联合ESWL较单用ESWL有更高的结石清除率[RR=1.29,95%CI(1.16,1.44)],其中6个试验分析提示试验组与对照组的结石清除时间无统计学差异[SMD=0.46,95%CI(-0.01,0.94)],3个试验分析提示试验组的疼痛评分比对照组较低[SMD=-1.02,95%CI(-1.27,-0.76)],9个试验分析提示试验组与对照组患者出现的不良反应无统计学差异[RR=3.51,95%CI(0.97,12.63)]。结论坦索罗辛联合ESWL比单用ESWL在治疗上尿路结石有更好的治疗效果,而且坦索罗辛联合ESWL可以减轻患者的疼痛,在一定程度上可以减少止痛药物的使用,试验中患者不良反应发生较少,患者耐受良好,表明坦索罗辛联合ESWL的安全性较好。更多还原

【Abstract】 Objective To evaluate and analyze the curative effects of using tamsulosin combined with ESWL(extracorporeal shock-wave lithotripsy) for the treatment of upper urinary tract calculi. Methods We collect relevant foreign randomized control groups by retrieving PubMed, MEDLINE, Wanfang database, CNKI database, VIP database, Embase and google database on the computer, included in the study and evaluated the quality of its methodology. At last, we used the statistical software of RevMan 4.2.2 to Meta analyze. Results We collected 13 randomized controlled trials(a total of 1322 patients), 7 in foreign countries, 6 in China.The Meta analysis showed that using tamsulosin combined with ESWL was higher than only using ESWL in calculi clearance rate[RR=1.29, 95% CI(1.16, 1.44)], in which 6 experiments’ analyses indicated that the calculi clearance time of the experimental groups and control groups had no statistic-al differences[SMD=-0.46, 95% CI(-0.01,-0.94)], in which 3 experiments’ analyses showed that the pain of experimental groups was lower than the pain of control groups[SMD=-1.02, 95% CI(-1.27,-0.76)], in which 9 experiments’ analyses suggested that the patients’ adverse reactions of the experimental groups and control groups had no statistical differences[RR =3.51, 95% CI(0.91, 12.63)]. Conclusion Using tamsulosin combined with ESWL has a better therapeutic effect than only using ESWL for the treatment of upper urinary tract calculi, and it can ease the pain of the patients and reduce the use of painkillers to some extent.In the experiment, there were fewer adverse effects in patients, and the patients were well tolerated, so it showed that the security of tamsulosin combined with ESWL is better.更多还原