【摘要】 目的探讨抗生素相关性肠炎(AAC)发生情况和相关因素,为临床合理使用抗菌药物提供参考。方法回顾性分析自2009年1月-2011年12月期间我院285例AAC和同期住院应用抗菌药物但无AAC发生的8932例患者的临床资料,以χ2检验、非条件Logistic回归等分析方法筛选出与AAC的发生相关的危险因素。结果 AAC是重要的院内感染之一,本次调查发病率为3.08%。AAC的发生与抗菌药物种类、联合用药情况、用药疗程、患者年龄、住院时间等危险因素相关。结论合理使用抗菌药物是防治AAC的关键。应注意对AAC患者进行综合性治疗。更多还原

【Abstract】 Objective To investigate the situation and related factors of antibiotic-associated colitis(AAC) in our hospital, and provide reference for rational use antibacterial agents in clinical. Methods The 285 cases of patients with AAC and 8932 cases who were given antibacterial agents but not demonstrated AAC from Jan 2009 to Dec 2011 in our hospital were respectively analyzed. χ2test and non-conditional logistic regression analysis were used to select risk factors that related to AAC. Results AAC is one of the most important hospital-acquired infections, it’s incidence is 3.08% in this investigation. The main factors for AAC are the kinds of antibacterial agents and it’s combination use, course of treatment, age of patients and length of their hospital stay, etc. Conclusions Rational use of antibacterial agents is the key to prevent AAC in hospital. It is important to note that AAC patients should be cured by comprehensive therapy.更多还原