【摘要】 目的:检测狼疮性肾炎患者外周血CD4+CD25high调节性T细胞的比例,探讨其临床意义。方法:采用流式细胞仪检测35例狼疮性肾炎患者及11名健康对照者的外周血CD4+CD25high调节性T细胞的比例,并分析其与肾脏病理类型和疾病活动的相关性。结果:狼疮性肾炎患者外周血CD4+CD25high调节性T细胞的比例与健康对照组相比,差异无统计学意义(P>0.05),并与疾病活动性无相关性。但III型和IV型狼疮性肾炎患者,CD4+CD25high调节性T细胞的比例较II型和V型患者明显降低(P<0.05)。结论:检测外周血CD4+CD25high调节性T细胞的比例可以辅助判断狼疮性肾炎的病理类型,并可为治疗狼疮性肾炎提供理论依据。更多还原

【Abstract】 Objective: To investigate the frequency of CD4+CD25high regulatory T cells in the peripheral blood of lupus nephritis patients with diverse pathology.Methods: Peripheral blood mononuclear cells from 35 lupus ne phritis patients based on the 2003 ISN/RPS classification system and 11 healthy controls were counted and stained for CD4 and CD25.The relation between CD4+CD25high regulatory T cells and renal pathology anddisease activity was analyzed.Results: No significant difference in the frequency of CD4+CD25high regulatory T cells was noted between the lupus nephritis patients and normal controls(P>0.05).Although the frequency of this cell pop ulations was not correlated to the disease activity(P>0.05),it was significantly decreased in lupus nephritis pa tients with Class III and IV when compared with patients with Class II and V(P<0.05).Conclusion: CD4+ CD25high regulatory T cells in the peripheral blood could be a promissory biomarker for active lupus nephritis pa tients and this may give rationale to use regulatory T cells as target cells in the treatment of lupus nephritis.更多还原