【摘要】 目的了解舟山海岛地区妊娠妇女的孕期甲状腺激素变化过程。方法选取孕妇358例,检测其孕早期、孕中期、孕晚期血清甲状腺激素,并按年龄分组用一般线性模型进行对比分析。结果孕晚期TT₃、TT₄、FT₃含量均高于孕早期和孕中期,差异有统计学意义（P<0.01）。24³0岁年龄组孕晚期TT₃、TT₄、FT₃含量均高于孕早期和孕中期,差异有统计学意义（P<0.01）。31岁以上年龄组孕早期TT₄、FT₄含量均低于0²3岁和24³0岁年龄组,差异有统计学意义（P<0.05或0.01）;孕晚期TT₃、TT₄含量31岁以上年龄组均低于0²3岁和24³0岁年龄组,差异有统计学意义（P<0.05或0.01）,FT₃、FT₄含量31岁以上年龄组低于24³0岁年龄组,差异有统计学意义（P<0.05）。结论加强对海岛地区孕妇孕晚期尤其是24³0岁育龄阶段孕晚期甲状腺激素的监测,有助于减少当地妊娠甲状腺疾病的发生。更多还原

【Abstract】 Objective To investigate the changes of thyroid hormones during early,middle and late gestation of pregnant women in Zhoushan city.Methods Serum thyroid hormone levels were measured during early,middle and late gestation of 358women in Zhoushan city.The results were analyzed with the General Linear Model.Results Serum levels of TT₃,TT₄ and TSH in late pregnant stage were significantly higher than those in early and middle stages（P<0.01）.Serum levels of TT₄ and FT₄ of ≥31age group in early gestation were significantly lower than those of≤23 and 24 30 groups（P<0.05 or 0.01）.Serum levels of TT₃and TT₄ of ≥31 group in late gestation were significantly lower than those of≤23 and 24 30 groups（P<0.05 or 0.01）,and serum levels of FT₃ and FT₄ of ≥31 group were significantly lower than those of 24 30 group（P<0.05）.Conclusion Monitoring serum thyroid hormone levels of pregnant women,particularly those at age of 24 to 30,would be necessary for prevention of thyroid disease.更多还原