【摘要】 目的探讨BAG-1与脑膜瘤瘤周水肿及术后复发的关系。方法取158例脑膜瘤病理标本,采用免疫组化SP法直接检测BAG-1的表达情况。按染色强度和阳性范围评估免疫组化检测结果,分析BAG-1表达水平[以免疫组化评分(IHS)表示]与脑膜瘤瘤周水肿及术后复发的关系。结果WHOⅠ级(上皮、纤维、混合、微囊、砂粒型)、Ⅱ级(不典型和脊索样型)、Ⅲ级(乳头型和间变型)的各亚型脑膜瘤BAG-1表达水平的差异有统计学意义(P<0 05或0.01)。术后复发患者24例,呈高表达状态3例(12.50%);未复发患者134例,呈高表达状态102例(76.12%)。术后复发者IHS增高者明显少于未复发者,差异有统计学意义(P<0.05)。瘤周水肿程度为0级与1级、2级与3级的患者其IHS高低例数分布的差异均无统计学意义(均P>0.05);但在0、1级与2、3级的两两比较中,差异均有统计学意义(均P<0.05)。结论脑膜瘤瘤周水肿及术后复发均与细胞凋亡有关,脑膜瘤BAG-1表达水平越低,其瘤周水肿越重,术后更易复发。更多还原

【Abstract】 Objective To investigate the relationship between BAG-1 expression with postoperative recurrent and peritumoral edema in patients with meningioma.Methods The expression of BAG-1 was detected with immunohistochemical SP method in brain tissue specimens from 158 patients with meningioma.The relationship of BAG-1 expression in meningioma with peritumoral edema and postoperative recurrence was analyzed.Results There was significant difference in BAG-1 expression degree between grade Ⅰ meningioma(including epithelial,fibrillar,mixed,microcystic and psammomatous subtypes) and grade Ⅱ(atypical,chordoid subtypes) or grade Ⅲ(papillary,anaplastic subtypes)(P<0.05 or 0.01).High degree BAG-1 expression in postoperative recurrence cases and no-recurrence cases were 12.50%(3/24) and 76.12%(102/134),respectively(P<0.05).There was no significant difference in expression degree of BAG-1 between peritumoral edema grade 0 and grade 1 or grade 2 to grade 3(all P >0.05).But the expression degree of BAG-1 between peritumoral edema grade 0 or 1 and the grade 2 or 3,the difference had statistical significance(all P<0.05).Conclusion The expressions of BAG-1 are negatively correlated with peritumoral edema and postoperative recurrent in meningrioma.更多还原