【摘要】 目的探讨体重指数(BMI)异常对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法回顾接受垂体降调节长方案IVF-ET治疗的738例不孕患者共807个周期,根据BMI标准分为3组:低体重组(BMI<18.5 kg/m2)184个周期,正常组(18.5kg/m2≤BMI<24 kg/m2)457个周期,超重组(BMI≥24 kg/m2)166个周期,所有患者均接受促性腺激素释放激素激动剂(GnRH-a)联合重组卵泡刺激素(rFSH)及人绝经期促性腺激素(HMG)的垂体降调节长方案促排卵治疗。比较3组患者的卵巢反应性、胚胎情况及妊娠结局。结果超重组Gn用量及使用天数均高于正常组,但差异无统计学意义(P>0.05)。3组间获卵数、受精率、卵裂率相似。超重组生化妊娠率、临床妊娠率、胚胎种植率、活产率均明显低于正常组,差异均有统计学意义(均P<0.05),低体重组虽低于正常组,但差异无统计学意义(P>0.05)。超重组流产率高于正常组,但各组间差异无统计学意义(P>0.05)。结论低体重或超重可对IVF-ET治疗的生化妊娠率、临床妊娠率、胚胎种植率、活产率、流产率等妊娠结局造成负面影响。更多还原

【Abstract】 Objective To assess the effects of abnormal body mass index(BMI) on reproductive outcomes in in vitro fertilization-embryo transfer(IVF-ET).Methods The clinical data of 807 IVF/intracytoplasmic sperm injection(ICSI) cycles from738 infertile couples were retrospectively analyzed.According to body mass index of females,total 807 cycles were divided into 3groups:underweight group(BMI<18.5kg/m~2,n=184),normal group(18.5kg/m~2≤BMI<24kg/m~2,n=457) and overweight group(BMI≥24kg/m~2,n=166).Response of ovarian,embryo quality,and reproductive outcomes were compared among groups.Results There were no differences in total number of oocytes and embryos,the rates of fertilization and cleavage among 3 groups.The biochemical pregnancy,clinical pregnancy,implantation and live birth rates were significantly poorer in overweight group than those in normal group(P<0.05).This trend existed in underweight group,however,all the differences were not significant(P >0.05).Compared to normal group,the miscarriage rate in overweight was higher,but no difference was found among three groups(P >0.05).Conclusion In females with abnormal BMI may have impaired reproductive outcomes as reduced biochemical pregnancy,clinical pregnancy,implantation and live birth rates,and elevated miscarriage rate in IVF-ET.更多还原