【摘要】 目的 探讨正五聚蛋白-3(PTX-3)、血脂在急性冠状动脉综合征中的临床意义,并根据冠状动脉造影结果了解其与冠状动脉病变程度是否相关。方法 入选经冠状动脉造影患者80例,测定血浆PTX-3浓度及各项血脂水平,比较各组间差异;冠心病3组患者按Gensini标准对冠状动脉病变程度进行积分,了解PTX-3水平是否与冠状动脉严重程度相关。结果 稳定型心绞痛(SAP)组PTX-3浓度(3.26±0.32)μg/mL与正常对照组(2.27±0.47)μg/mL比较差异无统计学意义(P>0.05);不稳定型心绞痛(UAP)组PTX-3浓度(4.77±0.63)μg/mL显著高于SAP组、正常对照组(P<0.05);急性心肌梗死(AMI)组PTX-3浓度(6.10±0.45)μg/mL显著高于UAP组、SAP组、正常对照组(P<0.05)。患者血浆PTX-3与低密度脂蛋白-胆固醇(LDL-C)水平存在正相关(r=0.641,P<0.05),与总胆固醇(TC)、甘油三酯(TG)无线性相关(P均>0.05)。经Speamman相关分析表明,冠状动脉病变严重程度与PTX-3水平无明显相关性,而LDL-C水平与冠状动脉病变程度存在相关性。结论 血浆PTX-3浓度可以反映冠状动脉粥样硬化的炎症程度,而与冠状动脉病变程度无明显相关性。更多还原

【Abstract】 Objective To study the clinical significance of pentraxin- 3 and blood lipid level in the patients with acute coronary syndrome(ACS),and to analyze the relationship between pentraxin 3 levels and the severity of coronary artery lesion according to angiography.Methods The study included 80 subjects who underwent coronary angiography,and their serum pentraxin- 3 levels and blood lipids(TG,TC and LDL-C) were measured.Gensini standard was used to evaluate the severity of coronary artery lesions,so that its correlation to serum PTX-3 could be analyzed.Results The PTX-3 levels between the stable angina pectoris(SAP) group and control group were not statistically significant [(3.26 ±0.32) μg/mL vs(2.27 ± 0.47) μg/mL,P > 0.05].But the serum PTX- 3 level was significantly higher in patients with unstable angina pectoris[UAP,(4.77 ±0.63) μg/mL]than that in SAP and control patients(P < 0.05);the serum PTX- 3 level in patients with acute myocardial infarction[AMI,(6.10 ±0.45) μg/mL]was the highest among all the groups and showed statistical significance when compared to the others(P < 0.05).It was noteworthy that PTX- 3 levels showed significant correlation to LDL- C(r=0.641,P < 0.05),although it did not correlate to TG and TC. The spearman correlation analysis showed that there was no significant correlation between serum PTX 3 levels and the severity of coronary artery lesions.But the plasma LDL- C and the coronary artery lesion appeared to be closely correlated.Conclusion Serum pentraxin- 3 levels reflect the degree of inflammation of coronary artery atherosclerosis,but not significantly correlated with the severity of coronary artery lesions..更多还原