【摘要】 目的 探讨负荷剂量瑞舒伐他汀对不稳定型心绞痛(UAP)患者经皮冠状动脉介入治疗(PCI)术后炎症因子的影响。方法 选择我院住院的UAP患者68例,随机分为对照组(术前不予瑞舒伐他汀,术后给予10 mg/d,n=34)和强化瑞舒伐他汀组(术前2d给予20 mg/d,术后给予10 mg/d,n=34)。分别于PCI术前、术后18~24 h检测心肌损伤标志物cTnI、CK-MB以及超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、血清干扰素-γ(IFN-γ)等炎症因子的表达。结果①PCI术后18~24 h,强化瑞舒伐他汀组患者cTnI高于正常高值的发生率低于对照组(P<0.05)。术后CK-MB两组比较差异无统计学意义(P>0.05)。②PCI术后18~24 h,hs-CRP、TNF-α、IFN-γ均较术前进一步升高,对照组较强化瑞舒伐他汀组升高明显,两组各项指标比较差异有统计学意义(P<0.05)。结论PCI术前给予20 mg瑞舒伐他汀可以有效地降低炎症因子hs-CRP水平及术后心肌损伤的发生率。更多还原

【Abstract】 Objective To investigate the effects of loading- dose rosuvastatin on inflammatory cytokines from unstable angina patients after percutaneous coronary intervention(PCI).Methods A total of 68 unstable angina patients were enrolled.Unstable angina patients were randomized to control group(n = 34) or pretreatment with loading- dose rosuvastatin group(20 mg/d,n = 34).cTnl,CK MB,hs- CRP,TNF- α and IFN-γ were measured respectively before PCI and 18-24 h post PCI. Results ①Compared with control group,rosuvastatin effectively reduced cTnl elevating after PCI(P < 0.05).The CK- MB level was not statistically different between the two groups after PCI(P > 0.05). ?The serum levels of hs- CRP,TNF-α and IFN- γ were all increased in both groups after PCI. However,levels of hs- CRP,TNF-α and IFN-γ in control group were higher than those in rosuvastatin group after PCI(P < 0.05).Conclusion Loading- dose rosuvastatin(20 mg) pretreatment can reduce post- PCI myocardial inflammation and periprocedural myocardial injury effectively.更多还原