【摘要】 介绍一种合成左氧氟沙星的新工艺。以(2,3,4,5)-四氟苯甲酰氯为起始原料,与3-乙氧基丙烯酸乙酯反应,然后L-氨基丙醇进行胺化反应,环合、水解后与N-甲基哌嗪缩合制得左氧氟沙星,总收率为50.15%。该工艺操作简单,环境污染小,符合绿色化学发展方向,值得进一步研究和推广。更多还原

【Abstract】 New process for preparing Levofloxacin was described.The target was prepared from(2,3,4,5)fluorobenzoic chloride,which reacted with ethyl 3-ethoxyacrylate,amination with S-(+)-2-aminopropanol,cyclization,hydrolysis and condensation with N-methyl piperazine.The total yield was 50.15%.The process has many advantages,such as simple operation,less environmental pollution.In line with the green chemistry development direction,it deserves further research and popularization.更多还原