OBJECTIVE To study the change of distribution and characteristics of drug resistance of the bacterial strains in NICU during the recent 4 years so as to provide clinical basis for the proper use of antibiotics and proper experience-based prescription.METHODS During the four years from Jan 2008 to Dec 2011,totally 1722 strains of non-repeated clinically isolated pathogens were collected in the NICU,which have been divided into two groups based on the time period,the characteristics of the change of the patho...