【摘要】 目的研究医院近3年肛周脓肿致病菌的分布、变迁及药敏变化特点,为其围球期抗菌药物的应用提供依据。方法回顾性分析医院2008年6月-2011年6月收治肛周脓肿行脓液培养的患者61例,分类整理其临床资料及药敏试验结果,比较不同年份细菌谱及耐药性,使用SPSS 17.0统计软件,采用Kruskal-Wallish test检验方法分析其差异。结果 3年来肛周脓肿细菌谱构成比及药敏率差异均无统计学意义;2008-2011年大肠埃希菌在肛周脓肿的细菌中所在比例分别为60.0%、66.7%、50.0%,其中产ESBLs大肠埃希菌比例有增加趋势,分别为33.33%、50.00%、52.38%,但差异无统计学意义;位于前3位的革兰阴性菌为大肠埃希菌、奇异变形菌和克雷伯菌属,分别占59.68%、11.29%、6.45%;大肠埃希菌对氨苄西林、庆大霉素、氨曲南、喹诺酮类和第一、二、三代头孢菌素均有较高的耐药率,但对亚胺培南、阿米卡星、含酶抑制剂类抗菌药物有较高的敏感性。结论肛周脓肿主要致病菌仍以大肠埃希菌为主,其细菌谱无明显改变;近3年病原菌对主要抗菌药物耐药率无显著变化。更多还原

【Abstract】 OBJECTIVE To investigate the distribution of the pathogens causing perianal abscesses as well as the characteristics of drug susceptibility in the recent three years so sa to provide basis for the wse of anfibiotics cluriny the perioperative period.METHODS A total of 61 patients with perianal abscesses who enrolled hospital from Jun 2008 to Jun 2011 were included.The clinical data and the results of drug sensitivity testing were recorded,the bacterial spectrum and the drug resistance in different years were compared;By means of SPSS 17.0,the Kruskal-Wallish test was employed to analyze the differenles.RESULTS There was no statistical difference in the constituent ratio of the bacteria spectrum and the drug susceptibility rate in the recent three years;Escherichia coli took the proportion of 60.0%,66.7%,and 50.0% respectively from 2008 to 2010,among which ESBLs-producing E.coli kept an upward tendency,accounting for 33.33%,50.00%,and 52.38%,respectively,the difference was not statistically significant;the top three species of gram-negative bacteria were E.coli(59.68%),Proteus mirabilis(11.29%) and Klebsiella(6.45%),respectively;E.coli was found to be highly resistant to ampicillin,gentamycin,aztreonam,quinolinones,the first,second and third generation cephalosporin,while which was highly susceptible to imipenem,amikacin,and inhibitor-containing antibiotics.CONCLUSION E.coli remains as the predominant species of pathogens causing perianal abscesses,but bacterial spectrum does not change significantly;the drug resistance rate of the pathogens to the main antibiotics does not change significantly in the recent three years.更多还原