【摘要】 目的评价多西他赛和奥沙利铂联合治疗晚期或复发胃癌的疗效和毒副作用。方法入组25例晚期或复发胃癌患者。用多西他赛75mg/m2,第1d;奥沙利铂,130mg/m2,第2d,21d为1周期。结果 25例患者可评价疗效。总有效率为52.0%(13/25),疾病控制率为96.0%(24/25)。中位疾病进展时间(TTP)和总生存期(OS)分别是6.8月和14.1月。主要的毒性反应是白细胞减少、中性白细胞减少、恶心、呕吐、脱发和感觉神经病,以Ⅰ～Ⅱ度为主。结论多西他赛联合奥沙利铂一线治疗晚期或复发胃癌有较好的临床疗效和可接受的毒性。更多还原

【Abstract】 Objective To evaluate the efficacy and toxicities of combination therapy with docetaxel and oxaliplatin in patients with advanced or recurrent gastric cancer.Methods Twenty-five patients with advanced or recurrent gastric cancer were enrolled.Patients received docetaxel,75mg/m 2,on day 1 and oxaliplatin,130mg/m 2,on day 2 every 3 weeks.Results All 25 patients were assessable for response.The overall response rate was 52.0%(13/25) and the disease control rate was 96.0%(24/25).Median time to progression(TTP) and overall survival(OS) were 6.8 months and 14.1 months,respectively.The major toxicities were leukopenia,neutropenia,nausea,vomit,alopecia and sensory neuropathy.The main toxicity was grade 1 to 2.Conclusion The combination of docetaxel and oxaliplatin have good clinical activity with acceptable toxicity in patients with advanced or recurrent gastric cancer.更多还原