【摘要】 目的探讨孕激素受体a(PR-a)、孕激素受体b(PR-b)在乳腺浸润性导管癌(IDC)中的表达及其与各临床病理指标的相关性,探讨PR亚型与预后的关系。方法采用免疫组化法检测100例IDC组织中PR-a、PR-b的表达,分析其与雌激素受体α(ER-α)、雌激素受体β(ER-β)、人类表皮生长因子受体2(HER-2)、核增殖抗原Ki-67、淋巴结转移、细胞学分级、TNM分期及脉管癌栓的相关性,研究PR-a/PR-b比值与各指标的关系。结果PR-a阳性55例(55%),PR-b阳性58例(58%)。PR-a与HER-2、Ki-67的表达呈正相关(P<0.05),与淋巴结转移负相关(P<0.05),与ER-β及脉管癌栓负相关(P<0.01),与ER-α、细胞学分级、TNM分期无相关;PR-b与淋巴结转移、细胞学分级、TNM分期负相关(P<0.05),与HER-2、Ki-67及脉管癌栓亦呈负相关(P<0.01),与ER-α、ER-β无相关。PR-a/PR-b>1者32例(48.5%),=1者18例(27.3%),<1者16例(24.2%)。PR-a/PR-b>1组的HER-2、Ki-67、高细胞学分级、高TNM分期、淋巴结阳性率高于PR-a/PR-b≤1组(P<0.05)。结论 PR-b的表达与HER-2、Ki-67、淋巴结转移、细胞学分级、TNM分期及脉管癌栓均呈负相关,而PR-a与各指标的相关性各不相同,PR-b阳性及PR-a/PR-b≤1可作为IDC预后良好的指标。更多还原

【Abstract】 Objective To investigate the expressions of progesterone receptor a and b in breast invasive ductal carcinoma(IDC) and their associations with clinical and pathological factors and prognosis.Methods The expressions of PR-a and PR-b in 100 specimens of IDC were detected by immunohistochemistry.The correlations between PR-a,PR-b and characteristics such as ER-α,ER-β,HER-2,Ki-67,axillary lymph node(ALN)metastases,cytological classification,TNM staging and lymphovascular invasion were analyzed,the relationships between PR-a/PR-b ratio and these factors were investigated.Results The expression rates of PR-a and PR-b were 55% and 58% respectively.The results showed positive correlation between PR-a and HER-2,Ki-67(P<0.05),and negative correlation between PR-a and ALN metastases(P<0.05),ER-β,lymphovascular invasion(P<0.01),but irrelevant with ER-α,cytological classification,TNM staging.The results also showed that PR-b was negatively correlated with ALN metastases,cytological classification,TNM staging(P<0.05),lymphovascular invasion,HER-2 and Ki-67(P<0.01),although irrelevant with neither ER-α nor ER-β.The number of PR-a/PR-b > 1,=1 and<1 was 32(48.5%),18(27.3%) and 16(24.2%) respectively.In PR-a/PR-b > 1 group,the positive rates of HER-2,Ki-67,high cytological classification,high TNM staging and ALN metastases were higher than PR-a/PR-b ≤ 1 group(P<0.05).Conclusions The expression of PR-b is negatively correlated with HER-2,Ki-67,ALN metastases,cytological classification,TNM staging and lymphovascular invasion.PR-b positive and PR-a/PR-b ≤ 1 can be good indicators of prognosis for IDC.更多还原