【摘要】 目的观察卡培他滨联合放疗在乳腺癌脑转移患者治疗中的疗效和毒副反应。方法收集青岛大学医学院第二附属医院肿瘤科和威海四零四医院肿瘤中心2008年6月至2010年4月收治的32例乳腺癌脑转移患者,14例经卡培他滨联合放疗治疗,18例经其他化疗药物联合放疗治疗,采用SPSS 17.0软件分析两组近期疗效、中位生存期和毒副反应。结果中位随访9个月,放疗联合卡培他滨组和放疗联合其他化疗组有效率分别为64%和61%,中位生存期分别为10.86个月和11.67个月,两组有效率无统计学差异(χ2=0.020,P>0.05),生存期差异亦无统计学意义(P=0.081)。放疗联合卡培他滨组消化道反应及骨髓折制轻于其他药物联合放疗组(χ2=4.773、4.114,P均<0.05),平均住院时间明显缩短(t=7.403,P<0.05)。结论卡培他滨联合放疗治疗乳腺癌脑转移具有较好的疗效,不良反应较其他药物联合放疗方案轻。更多还原

【Abstract】 Objective To observe the efficacy and safety of capecitabine and radiation on brest cancer transferred to brain. Methods Thirty-two cases with the above disease were collected. 14 of them were treated with capecitabine and radiation. The response rates,median overall survival (OS),and side effects were analyzed. Results The two groups had similar overall response rate( 64% vs. 61%,χ2= 0. 020,P > 0. 05) and median overall survival (10. 86 months vs. 11. 67 months)(P > 0. 05). The side effects of those had capecitabine and radiation was significantly lower than others (χ2= 4. 773,4. 114,all P < 0. 05),and the capecitabine and radiation group had less time in hospital (t = 7. 403, P < 0. 05).Conclusion Capecitabine and radiation is a feasible and effective treatment for brest cancer transferred to brain,and side effects are significantly lower than other chemotherapy drugs.更多还原