【摘要】 目的探讨广东潮州农村妇女宫颈感染高危型人乳头瘤病毒(HPV)情况及其危险因素,为该地区制定预防宫颈癌的公共卫生策略提供依据。方法选择2010年3月至10月广东潮州农村12 542例符合本研究纳入标准的35～59岁女性为研究对象。对其通过荧光定量PCR法进行宫颈13种高危型HPV免费检测,进行危险因素问卷调查,并对相关结果采用χ2检验和非条件多因素logistic回归分析方法进行危险因素分析(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,并与受试者签署临床研究知情同意书)。结果本组12 542例受检妇女中,13种高危型HPV感染率为8.06%(1011/12 542),非条件多因素logistic回归分析结果显示,高危型HPV感染的高危因素包括:孕次≥3次[OR=1.24,95%CI(1.09～1.41),P<0.01],初婚年龄<24岁[OR=1.16,95%CI(1.01～1.32),P=0.03],宫颈外观异常[OR=1.21,95%CI(1.05～1.39),P=0.01],妇科手术史[OR=1.68,95%CI(1.15～2.46),P=0.01],丈夫饮酒[OR=1.45,95%CI(1.27～1.65),P<0.01],未予定期接受妇科病检查[OR=1.43,95%CI(1.08～1.88),P=0.01],很少进行妇科病检查[OR=1.81,95%CI(1.26～2.60),P<0.01]及丈夫从事职业为管理者、文员或公务员[OR=1.71,95%CI(1.24～2.37),P<0.01]。结论广东潮州农村35～59岁女性宫颈感染高危型HPV较为常见。其中,孕次≥3次、初婚年龄<24岁、宫颈外观异常、妇科手术史、未予定期或很少接受妇科体检、丈夫饮酒及丈夫从事职业为管理者、文员或公务员的农村女性的高危型HPV感染率较高。更多还原

【Abstract】 Objective To investigate the prevalence and risk factors of high risk human papilloma virus(HPV)among women in rural area of Chaozhou city,Guangdong province and provide scientific evidence for public health strategy in rural area of China.Methods From March to October 2010,a total of 12 542 women aged 35-59years old in rural area of Chaozhou city,Guangdong Province in China were recruited.They were free detected the 13kinds of high risk HPV type in cervix by real-time quantitative PCR with fluorescent test,and investigated the risk factors face to face by questionnaire,then analyzed the risk factors byχ2 test and multiple factor unconditional logistic regression model.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Guangdong Women and Children Hospital.Informed consent was obtained from all participants.Results Among 12 542detected women,the prevalence of 13 kinds of high risk HPV was 8.06%(1011/1254).Through multiple factor unconditional logistic regression model analyzed,it showed risk factors on high risk HPV infected including gravidity equal or more than three times[OR=1.24,95%CI(1.09-1.41),P<0.01],first marriage age less than 24years old[OR=1.16,95%CI(1.01-1.32),P=0.03],cervical appearance abnormal[OR=1.21,95%CI(1.05-1.39),P=0.01],gynecological surgery history[OR=1.68,95%CI(1.15-2.46),P=0.01],husband drink[OR=1.45,95%CI(1.27-1.65),P<0.01],received irregularly gynecological diseases examination[OR=1.43,95%CI(1.08-1.88),P=0.01],less participation of gynecological diseases examination[OR=1.81,95%CI(1.26-2.60),P<0.01]and husband′s occupation was manager or clerk or civil servant[OR=1.71,95%CI(1.24-2.37),P<0.01].Conclusions High risk HPV infections among women aged 35-59years old in rural area of Chaozhou city were frequently,there was a higher infected rate of high risk HPV in rural women who had gravidity equal or more than three times,cervical appearance abnormal,gynecological surgery history,irregularly or less participation of gynecological diseases examination,husband drink and his occupation was manager,clerk or civil servant.更多还原