【摘要】 目的:观察蜂蜡麻油敷料对大鼠皮肤溃疡创面愈合的影响。方法:于大鼠背部制备3个缺损性皮肤溃疡,分别设为生理盐水敷料组、凡士林敷料组、蜂蜡麻油敷料组,每2d换药1次,换药前摄像,每隔1周取标本1次,ELISA测定EGF的含量。结果:第14、21d时大鼠皮肤创面愈合率,蜂蜡麻油组与其他两组比较有显著差异(P<0.01和P<0.05);第7、14、21d麻油蜂蜡组创面EGF含量较凡士林组、生理盐水组升高,差异有统计学意义;免疫组化发现麻油蜂蜡组创面细胞中EGF表达增加,定量分析有统计学差异。结论:蜂蜡麻油敷料有促进大鼠皮肤溃疡创面愈合的作用,其机制可能是通过保持湿润和营养来实现的。更多还原

【Abstract】 Objective To observe the beeswax and benne oil dressing in rat skin ulcer healing.Methods Three skin ulcer wounds were made on the back of the rat,the upper left,the upper right,and the lower left side were set to the saline group,the geoline group and the beeswax and benne oil group respectively.Dressing change was done every two days,photograph taken before dressing,and samples taken at intervals of one week.The epidermal growth factors(EGF) were determined by ELISA.Results On the seventh day,all the three groups on the rate of wound healing were not statistically different (P > 0.05).On the fourteenth and twenty-first days,the rate of wound healing was highest in the beeswax and benne oil group,the rate of the beeswax and benne oil group as comparing with those of the other two groups was significantly different(P < 0.01 and P < 0.05).On the seventh,fourteenth and twenty-first day of the experiment,the epidermal growth factor was highest in the beeswax and benne oil group,with significant differences from the other two groups.Conclusion Beeswax and benne oil dressing can promote the skin ulcer healing,beeswax and benne oil can be used as materials of dressing that should be widely used clinically,its effect maybe achieved through keeping wound moist and nutrition.更多还原