【摘要】 上皮细胞间充质转化(epithelial-mesenchymal transition,EMT)在胚胎发育和肿瘤发生中具有重要作用,EMT可使上皮性肿瘤细胞获得间充质细胞表型,在增强肿瘤细胞的侵袭和转移能力的同时,也使得肿瘤细胞具有自我更新能力等干细胞样特性。多种转录因子、信号转导通路、microRNAs及细胞微环境等因素共同调控此过程。EMT与肿瘤干细胞之间有密不可分的联系,EMT可以促进肿瘤细胞获得干细胞特征,具有干细胞特征的肿瘤细胞高表达EMT标记分子,microRNA可同时调控EMT和细胞干性。阐明EMT与肿瘤干细胞的相互关系及其调控机制,有望为肿瘤转移与复发的靶向治疗开辟新思路。更多还原

【Abstract】 Epithelial-mesenchymal transition(EMT) is an important biological process in embryonic development and tumorigenesis.In this process,epithelial tumor cells can obtain mesenchymal phenotypes and promote tumor invasion and metastasis.EMT is controlled by multiple transcription factors,signal pathways,and microRNAs.EMT and cancer stem cells are closely related.EMT also promotes the self-renewal ability of tumor cells and the overexpression of EMT-related markers in tumor cells with stemness.Some microRNAs can control EMT process and stemness.In this study,recent developments on EMT and cancer stem cells in tumor metastasis were summarized to provide new insights into target therapy of tumor metastasis and recurrence.更多还原