【摘要】 目的观察酒石酸长春瑞滨脂质体注射液的体内抗肿瘤作用。方法建立小鼠肝癌H22肿瘤模型和人大细胞肺癌NCI-H460移植肿瘤模型,探讨长春瑞滨脂质体的抗肿瘤作用。结果长春瑞滨脂质体单次以20、10、5和2.5 mg·kg-1静脉注射,对小鼠H22实体瘤的抑瘤率分别是82.1%、75.8%、63.2%和35.4%,酒石酸长春瑞滨注射液(20和10 mg·kg-1)的抑瘤率分别是45.8%和37.1%。长春瑞滨脂质体8 mg·kg-1间隔3 d静脉给药3次,可以显著抑制NCI-H460肿瘤的生长。长春瑞滨脂质体对H22肿瘤和NCI-H460的抑制作用明显优于长春瑞滨游离药,且与给药剂量正相关。结论相同给药剂量下,长春瑞滨脂质体的体内抗肿瘤作用显著优于长春瑞滨注射液。更多还原

【Abstract】 OBJECTIVE To explore the anti-tumor efficacy of liposomal vinorelbine tartrate injection( NVB-lipo). METHODS The anti-neoplastic effect of NVB-lipo was evaluated by using mice bearing H22 tumor and nude mice bearing NCI-H460 human xenograft tumor model. RESULTS After a single intravenous injection at doses of 20,10,5 and 2. 5 mg·kg- 1,the inhibition ratio of H22 tumor were 82. 1%,75. 8%,63. 2% and 35. 4% respectively,and that of NVB-free( 20 and 10 mg·kg- 1) were 45. 8% and37. 1%. After three times iv injection interval 3-day,NVB-lipo 8 mg·kg- 1could markedly inhibited the growth of NCI-H460 tumor,relative to control and NVB-free( P < 0. 05). The anti-tumor effect of NVB-lipo in H22 and NCI-H460 tumor model was much stronger than NVB-free,and was positively correlated with its dose levels. CONCLUSION At the same dose level,the antineoplastic effects of NVB-lipo is stronger than NVB-free.更多还原