【摘要】 目的通过对安徽省铜陵市第四人民医院上报的儿童药物不良反应进行回顾性分析,为儿童临床安全合理用药提供理论依据。方法对我院门诊注射室、儿科病房在2011~2012年度上报的91例15岁以下患儿的药物不良反应病历进行统计分析。结果0~3岁患儿发生药物不良反应的比例最高,有50例;β-内酰胺类引起的药物不良反应最多,有72例;91例均由静脉给药引起;累及器官主要以皮肤、粘膜及附件的损害最多,有86例。结论儿童药物不良反应的发生与药物的用法、用量有关,抗生素的用量过大及不规范使用是造成儿童药物不良反应的主要原因。临床医师应熟悉儿童的生理特征,加强药物的合理使用,减少儿童药物不良反应的发生。更多还原

【Abstract】 Objective To provide theory basis for safe and reasonable clinical medication for children through a retrospective analysis of the case reports on adverse drug reaction in children in the Fourth People′s Hospital of Tongling.Methods A statistical analysis was performed on the case history of the 91 cases of adverse drug reaction in children under 15 years reported by the injection room of the outpatient department of our hospital and the pediatric ward in 2011-2012.Results The highest occurrence of ADR in children was in those between 0-3 years,which was 50 cases;72 cases of ADR were caused by Beta- lactam drugs;all the 91 cases of ADR were caused by intravenous administration of drugs;ADR involving organ damage mainly occurred in the skin,mucous membranes and accessories,accounting for 86 cases. Conclusion The occurrence of ADR in children is associated with drug use and dosage of the drugs. Excessive use and non-standardized use of antibiotics are the major causes of ADR in children.Clinicians should be familiar with the physiological characteristics of children,strengthen the rational use of drugs so as to reduce the occurrence of ADR in children.更多还原