【摘要】 目的 比较来曲唑与克罗米芬诱导排卵的临床效果。方法 选择新疆维吾尔自治区人民医院符合标准的不孕症患者105例,完全随机分为来曲唑组(42例,口服来曲唑5 mg/d,连用5 d)和克罗米芬组(63例,口服用克罗米芬50 mg/d,连用5 d)。观察2组患者卵泡发育、子宫内膜生长情况,同时记录妊娠例数、流产例数、异位妊娠例数和继续妊娠。结果 来曲唑组与克罗米芬组相比,人绒毛膜促性腺激素注射日≥14 mm卵泡数明显减少,子宫内膜厚度较厚;2组均无卵巢过度刺激综合征的发生;来曲唑组妊娠率和继续妊娠率分别为21.4%(9/24)、14.3(6/42),均高于克罗米芬组的12.7%(8/63)和6.3%(4/63),但差异无统计学意义(P>0.05)。结论 来曲唑有类似克罗米芬的促排卵作用及相似的妊娠率,但来曲唑能否替代克罗米芬成为第一线诱导排卵药物,还需要多中心、大样本的临床研究。更多还原

【Abstract】 Objective To evaluate a new drug treating ovulation induction by comparing the effects and pregnancy outcome of letrozole versus clomiphere citrate for ovulation induction.Methods Totally 105 patients were randomly divided into the letrozole group with 42 patients(taking letrozole,5 mg/d,qd for 5 d) and clomiphene group of 63 cases(taking clomiphene,50 mg/d,qd for 5 d).Follicular development,endometrial growth indicators,the number of cases of pregnancy,miscarriage number of cases and the number of cases of ectopic pregnancy were recorded.Results Compared with clomiphene citrate group,the number of follicles which diameter were larger than 14 mm significantly reduced on the injection day of human chorionic gonadotropin and the endometrial thickness was larger in the letrozole group.The two groups had no incidence of ovarian hyperstimulation syndrome. The pregnancy rate and ongoing pregnancy rate were 21.4%(9/24) and 14.3%(6/42) in the letrozole group.But the pregnancy rate and ongoing pregnancy rate were 12.7%(8/63) and 6.3%(4/63) in the clomiphene group. The pregnancy rate and ongoing pregnancy rate were higher in the letrozole group than those in the clomiphene group.But the difference between the two groups were not statistically significant.Conclusions Letrozole results in stimulation of ovarian folliculogenesis and the pregnancy rate is similar to those with clomiphene citrate.Letrozole can avoid the unfavorable effects on the ovaries and endometrium.更多还原