【摘要】 目的 探讨肝癌晚期患者采用干扰素辅助经导管肝动脉化疗栓塞（TACE）的治疗效果。方法 将2011年2月至2012年8月确诊为病毒性肝炎肝癌晚期的96例患者。完全随机分为观察组和对照组,各48例。对照组患者多个常规TACE治疗;观察组患者在TACE基础上加用干扰素o皮下注射,（3⁵）×10¹⁰IU/m²,1次/d。疗程均为8周。观察患者治疗前及治疗4、8周甲胎蛋白（AFP）水平,疗程结束后进行疗效评价。结果 观察组治疗前和治疗4、8周后AFP分别为（446±89）、（101±55）、（70±28）μg/L,对照组分别为（452±91）、（151±44）、（112±32）μg/L。观察组治疗前AFP与对照组同期比较,差异无统计学意义（P>0.05）;观察组治疗4、8周与对照组同期比较,差异有统计学意义（P<0.05）。观察组和对照组总有效率分别为95.8%（46/48）、79.2%（38/48）,组间差异有统计学意义（P<0.05）。结论 干扰素辅助TACE可以有效控制肝癌晚期患者AFP的增长,抑制肿瘤增长。更多还原

【Abstract】 Objective To explore the curative effect of interferon auxiliary transcatheter arterial chemoembolization（TACE） in treatment of advanced liver cancer patients.Methods From February 2011 to August 2012, 96 patients of viral hepatitis in late liver cancer were enrolled in this study.All the patients were randomly divided into observation group and control group（48 cases in each group）.Patients in control group were treated with TACE,patients in observation group were treated with TACE and interferon alpha subcutaneous injection[（3-5） × 10¹⁰ IU/m²].The effect evaluation and alpha fetoprotein（AFP） before treatment and after treatment in 4,8 weeks were observed.Results AFP in the observation group before treatment and after treatment in 4,8 weeks was（446±89） μg/L,（101±55） μg/L,（70±28） μg/L;AFP in the control group were（452±91） μg/L,（151± 44）μg/L,（112±32） μg/L.There was no significant difference between observation group before treatment and control group（P>0.05）.AFP in the observation group after treatment in 4,8 weeks was significantly lower than that in control group during the same period（P <0.05）.Total effective rate in the observation group and the control group was 95.8%（46/48） and 79.2%（38/48） respectively;there was a statistically significant difference between the two groups（P<0.05）.Conclusion Interferon assisted TACE can effectively control AFP growth and tumor growth in the advanced liver cancer patients.更多还原