【摘要】 目的 观察吉非贝齐联合低剂量辛伐他汀治疗老年原发性混合型高脂血症的临床疗效。方法 选择2010年7月至2012年12月广东省深圳市福田区第二人民医院治疗的原发性混合型高脂血症老年患者(年龄≥65岁)150例,随机数字表法分为对照组(75例)与观察组(75例)。对照组服用辛伐他汀20 mg/d,观察组联合服用吉非贝齐300~600 mg/d、辛伐他汀10 mg/d,2组疗程均为6周。观察2组治疗后的总有效率、TC、TG、LDL-C、HDL-C以及血压变化情况。结果 治疗6周后,观察组总有效率为98.7%(74/75),对照组为92.0%(69/75),2组比较差异有统计学意义(P<0.05)。2组治疗后TC、TG、LDL-C、HDL-C水平[观察组:(4.6±0.5)、(1.2±0.3)、(2.4±0.6)、(1.5±0.3)mmol/L;对照组:(4.9±0.4)、(1.6±0.3)、(3.0±0.5)、(1.0±0.3)mmol/L]与治疗前[观察组:(7.1±0.6)、(2.3±0.3)、(4.1±0.4)、(0.9±0.4)mmol/L;对照组:(7.0±0.6)、(2.3±0.3)、(4.1±0.4)、(0.9±0.4)mmol/L]比较,差异均有统计学意义(均P<0.05)。观察组治疗后TC、TG、LDL-C、HDL-C与对照组比较,差异均有统计学意义(均P<0.05)。治疗后2组收缩压、舒张压[观察组:(132±7)、(83±6)mm Hg(1 mm Hg=0.133 kPa);对照组:(140±6)、(87±6)mm Hg]均低于本组治疗前[观察组:(156±10)、(97±8)rnn Hg;对照组:(157±8)、(96±6)mm Hg],差异有统计学意义(均P<0.05);治疗后观察组收缩压、舒张压与对照组比较,差异有统计学意义(均P<0.05)。结论 吉非贝齐联合低剂量辛伐他汀可有效改善老年原发性混合型高脂血症,降低TC、TG、LDL-C水平,提高HDL-C水平,并有效改善患者血压。更多还原

【Abstract】 Objective To observe the clinical efficacy of gemfibrozil combined with low doses of Simvastatin in the treatment of elderly patients with primary mixed hyperlipidemia.Methods One hundred and fifty elderly patients with primary mixed hyperlipidemia(age>65 years) in the second people’s hospital of Futian district in Shenzhen city from July 2010 to December 2012 were randomly divided into control group(75 cases) and the observation group(75 cases) by the random number table.The control group received simvastatin 20 mg/d.The observation group received gemfibrozil(300-600 mg/d) and simvastatin(10 mg/d).After six weeks,the total effective rate,total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoproteincholesterol(HDL-C) and blood pressure of two groups were compared.Results After 6 weeks of treatment, the total effective rate of observation group was 98.7%while the control group was 92.0%;the difference was statistically significant(P<0.05).There were significant differences on TC,TG,LDL-C,HDL-C levels between two groups[observation group:(4.6±0.5),(1.2±0.3),(2.4±0.6),(1.5±0.3)mmol/L;control group:(4.9± 0.4),(1.6±0.3),(3.0±0.5),(1.0±0.3) mmol/L]after treatment compared with those before treatment[observation group:(7.1±0.6),(2.3±0.3),(4.1±0.4),(0.9±0.4) mmol/L;control group:(7.0±0.6),(2.3±0.3),(4.1±0.4),(0.9±0.4)mmoI/L](P<0.05).There were significant differences on TC,TG, LDL-C,HDL-C levels of observation group after treatment compared with control group(P < 0.05).After treatment,systolic blood pressure and diastolic blood pressure of two groups[observation group:(132±7),(83±6) mm Hgjcontrol group:(140±6),(87±6)mm Hg]were lower than before treatment[observation group:(156±10),(97±8)mm Hgjcontrol group;(157±8),(96±6)mm Hg](P <0.05).There were significant differences on systolic blood pressure and diastolic blood pressure of observation group compared with control group(P < 0.05). Conclusions Gemfibrozil combine with low dose simvastatin is effective for the elderly patients with primary mixed hyperlipidemia.It can reduce the level of TC,TG,LDL-C,increase the level of HDL-C and effectively improve the patient’s blood pressure.更多还原