【摘要】 目的 分析硝苯地平、苯磺酸氨氯地平和美托洛尔3种不同药物治疗老年原发性高血压的成本-效果。方法 将180例老年原发性高血压患者完全随机分为硝苯地平组、苯磺酸氨氯地平组及美托洛尔组,每组60例。硝苯地平组予以硝苯地平治疗,1次/d,30 mg/次;苯磺酸氨氯地平组予以氨氯地平治疗,5 mg/次,1次/d;美托洛尔组予以美托洛尔治疗,50 mg/次,2次/d。治疗8周后,比较3组患者临床疗效,计算成本并进行成本-效果分析。结果 苯磺酸氨氯地平组有效率明显高于硝苯地平组、美托洛尔组[95.0%(57/60)比85.0%(51/60)、78.3%(47/60)],差异有统计意义(P<0.05)。硝苯地平组、苯磺酸氨氯地平组及美托洛尔组成本-效果比分别为3.57、2.32、1.54,增量成本-效果比硝苯地平组、苯磺酸氨氯地平组分别为18.22、5.94。结论 3种药物中,氨氯地平是治疗老年原发性高血压经济有效的最佳选择。更多还原

【Abstract】 Objective To study the cost-effect of nifedipine,amlodipine and metoprolol in the treatment of essential hypertension.Methods All 180 patients with essential hypertension were randomly divided into nifedipine group,amlodipine group and metoprolol group;each group had 60 cases.Nifedipine group was treated with nifedipine(30 mg per time,1 time per day),amlodipine group was treated with amlodipine(5 mg per time and 1 time per day) and metoprolol group was given metoprolol(50 mg per time,2 times per day).After 8 weeks,the clinical efficacy and cost-effect were compared.Results The clinical efficacy in amlodipine group was better than that in nifedipine group and metoprolol group[95.0%(57/60) vs 85.0%(51/60),78.3%(47/60),P <0.05];the cost-effectiveness among nifedipine group,amlodipine group and metoprolol group were 3.57,2.32 and 1.54.The incremental cost among nifedipine group,amlodipine group were 18.22 and 5.94.Conclusion Amlodipine has the best cost-effect in the three drugs for treatment of older essential hypertension.更多还原