【摘要】 目的:调查抗菌药物专项整治前、后某院社区获得性肺炎(CAP)住院患者抗菌药物的应用情况。方法:采用回顾性方法,查阅2011年6月(整治前)和2012年6月(整治后)某院住院CAP患者的出院病历,对抗菌药物的应用情况进行统计、分析。结果:整治后该院CAP患者平均住院时间由14.54d缩短至12.44d;平均抗菌药物疗程由18.00d缩短到12.67d;抗菌药物的使用强度(AUD)由154.43DDDs/100人/天下降到111.58DDDs/100人/天(P<0.01);抗菌药物平均费用由2690.31元下降至1666.96元(P<0.01);患者出院带药由31例次减少到12例次(P<0.01)。但在指标下降的同时,不按CAP指南选择药物治疗的问题仍然突出。结论:开展专项整治有助于促进抗菌药物应用管理;但医疗机构在控制指标的同时,尚需加强对抗菌药物临床应用合理性的评价。更多还原

【Abstract】 OBJECTIVE:To investigate the clinical application of antibacterials in hospitalized patients with community-acquired pneumonia (CAP) before and after special rectification.METHODS:By retrospective study,discharged medical records of CAP patients in a hospital were reviewed in Jun.2011 (before special rectification) and Jun.2012 (after special rectification).The use of antibacterials was analyzed statistically.RESULTS:After special rectification,the average hospitalization days of CAP patients was shortened from 14.54 d to 12.44 d;the average duration of antibacterials was shortened from 18.00 d to 12.67 d;AUD decreased from 154.43 DDDs/100 persons/day to 111.58 DDDs/100 persons/day (P<0.01);the average cost of antibacterials was decreased from 2 690.31 yuan to 1 666.96 yuan (P<0.01);and the number of discharge medication was decreased from 31 cases to 12 cases(P<0.01).While the indicators fell,the problem of drug selection which didn’t followed the guidelines was still outstanding.CONCLUSIONS:The special rectification helps to promote the use and management of antibacterials.However,medical institutions control indicators,at the same time need to strengthen the evaluation of rationality of antibacterials use.更多还原