【摘要】 目的探讨HIV/AIDS免疫病理的改变特点,为AIDS防治工作提供科学依据。方法以71例HIV感染者和54例AIDS患者为研究对象,并选取140例健康体检者为对照组,检测分析3组外周血CD4+、CD8+T淋巴细胞的变化及其临床意义。结果 CD4+细胞计数正常对照组[(670±361)个/μL]>HIV组[(378±235)个/μL]>AIDS组[(154±104)个/μL](P<0.01);CD8+细胞计数HIV组[(918±823)个/μL]明显高于正常成人组[(489±250)个/μL]与AIDS组[(512±319)个/μL](P<0.05);CD4+/CD8+的比值正常成人组(1.48±0.89)明显高于HIV组(0.41±0.37)和AIDS组(0.18±0.16)(P<0.05)。结论本地区HIV/AIDS患者T淋巴细胞亚群的变化过程与疾病进展有良好的相关性。更多还原

【Abstract】 Objective To study the immunopathological characteristics of HIV/AIDS and provide a scientific basis for the prevention and cure of AIDS. Methods 71 cases of HIV patients and 54 cases of AIDS patients were selected as the objects of our study, and 140 cases of healthy people were selected as normal control group. The changes of peripheral blood CD4+ and CD8+ T lymphocytes and its clinical significances were detected and analyzed. Results The CD4+ cell count show that the normal control group [(670 ± 361) /μL]> the HIV group [(378 ± 235) /μL]> AIDS group [(154 ± 104) /μL] (P < 0.01); the CD8+ cell count [(918 ± 823) /μL] of HIV group was obviously higher than the normal control group[ (489 ± 250) /μL]and AIDS group [(512 ± 319) /μL], (P < 0.05); the CD4+/CD8+ ratio of the normal control group (1.48 ± 0.89) was significantly higher than the HIV group (0.41 ± 0.37) and AIDS group (0.18 ± 0.16) (P < 0.05). Conclusion The changing process of T lymphocyte subsets and the progression of HIV/AIDS patient in this region have a good correlation.更多还原