【摘要】 目的观察分析子宫内膜癌手术后辅助放疗的疗效及并发症。方法回顾分析63例子宫内膜癌患者,术后均采用直线加速器盆腔野体外照射,46～50Gy/23f～25f。分析患者年龄、手术病理分期、肌层浸润、病理类型、淋巴结转移等因素与3年生存率的关系,并分析患者急性反应和晚期并发症。结果所有患者中Ⅰ期34例,Ⅱ期12例,Ⅲ期10例,Ⅳ期7例。组织病理学类型:内膜样腺癌57例,腺鳞癌2例,浆液性乳头状腺癌1例,乳头状腺癌2例,管状腺癌1例。全组患者3年总生存率为87.3%。手术病理分期、肌层浸润、淋巴结转移与术后生存率显著相关(P<0.05)。59例(93.7%)出现早期急性放射反应,8例(12.7%)出现晚期并发症。结论对于具有高危因素的子宫内膜癌患者,应根据具体情况制定合理准确的术后放疗方案,最大程度地提高疗效的同时保护正常组织免受不必要的受损,降低并发症,提高肿瘤治疗的增益比。更多还原

【Abstract】 Objective To observe and analyze the efficacy and complications of operation combined radiotherapy in treatment of endometrial carcinoma. Methods Sixty-three cases of endometrial cancer patients were retrospectively analyzed, they were taken pelvic portal vitro in exposure of the linear accelerator with 46-50 Gy/23f-25f. The relationship of three-year survival rate and some factors such as age, intraoperative judgments, myometrial invasion, pathological type, lympho node metastasis and other factors were analyzed. The acute response and late complications were analyzed also. Results In all patients, 34 cases were in stage Ⅰ, 12 cases were in stage Ⅱ, 10 cases were in stage Ⅲ, 7 cases were in stage Ⅳ. The histopathological types were: endometrioid adenocarcinoma in 57 cases, adenosquamous carcinoma in 2 cases, papillary serous adenocarcinoma in 1 case, papillary adenocarcinoma in 2 cases, tubular adenocarcinoma in 1 case. The overall three-year survival rate of all the patients was 87.3%. Intraoperative judgments, myometrial invasion and lympho node metastasis were significantly correlated with postoperative survival rate (P<0.05). Early acute radiation reactions occurred in 59 cases (93.7%), late complications occurred in 8 cases (12.7%). Conclusion In accordance with specific conditions, endometrial carcinoma patients with high risk factors should be given a reasonable and accurate postoperative radiotherapy regimen, in order to improve efficacy furthest and protect normal tissue, reduce the complications and improve the gain ratio in tumor therapy.更多还原