【摘要】 目的探讨新生儿窒息对肠道菌群及机体体液免疫的影响。方法选取26例新生儿窒息患儿及26例正常新生儿作为研究对象,分别于生后24～48h对其血清IgA、IgG和IgM进行检测。同时对其粪便进行培养,检测其双歧杆菌和肠球菌的菌落数量,并分析其与体液免疫之间的相关性。结果新生儿窒息患儿在生后24～48h,其血清IgA、IgM水平与正常新生儿相比均存在一定程度的降低。粪便培养结果显示,新生儿窒息患儿粪便中双歧杆菌和肠球菌所形成的菌落数量均较正常新生儿明显减少,并且其菌落数量与血清IgA、IgM水平之间呈明显的正相关。结论新生儿窒息造成了肠道菌群的定植的延缓,进而使机体的体液免疫产生了抑制作用。更多还原

【Abstract】 Objective To investigate the influence of neonatal asphyxia on enterobacteria and humoral immunity. Methods Twenty-six patients of neonatal asphyxia and 26 normal newborns were selected randomly. The serum IgA, IgG and IgM were detected from 24 to 48 hours after born. Meanwhile, excrement was culture in vitro to detect the bacterial colony number of bacillus bifidus and enterococcus. The correlation between bacterial colony number and humoral immunity was analyzed. Results In neonatal asphyxia group, 24 to 48 hours after born, the level of serum IgA and IgM was decreased compared to normal newborns. Excrement culture shown that the bacterial colony number of bacillus bifidus and enterococcus was decreased too, and positively correlated with serum IgA and IgM. Conclusion Neonatal asphyxia could postpone the field planting of enterobacteria, and then inhibit the humoral immunity.更多还原