【摘要】 目的观察糖尿病周围动脉病变(PAD)患者中血小板计数、血小板平均体积(MPV)及血小板分布宽度(PDW)的变化情况。方法 171例T2DM患者根据踝肱指数(ABI)分为重度病变(ABI<0.4,A)组18例,轻度病变(0.4≤ABI≤0.9,B)组80例,以及正常对照(0.9<ABI<1.3,C)组73例,比较3组间BMI、HbA1c、TC、TG、LDL-C、HDL-C、血小板计数、MPV、PDW。结果 A、B组MPV分别为(13.69±0.57)、(11.22±1.42),高于C组(9.87±1.62)(P<0.05),A组高于B组(F=23.96,P<0.05)。A、B组PDW分别为(17.14±1.76)、(16.40±3.18),与C组(23.76±2.76)比较,差异无统计学意义(F=0.18,P=0.83);A、B组血小板计数分别为(182.12±12.11)、(179.67±15.99),与C组(177.54±14.87)比较,差异无统计学意义(F=0.23,P=0.79)。结论随着PAD的加重,T2DM患者MPV水平升高。更多还原

【Abstract】 Objective To observe the changes of platelet count,mean platelet volume(MPV)and platelet distribution width(PDW)in T2DM patients with peripheral artery disease(PAD). Methods According to ankle brachial index(ABI),171T2DM patients were divided into three groups:severe lesion(A)group(ABI<0.4,n=18);mild lesion(B)group(0.4≤ABI≤0.9,n=80)and normal control(C)group(0.9<ABI<1.3,n=73).Body mass index(BMI),glycated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),platelet count,MPV and PDW were measured and compared among three groups.Results Compared with the group C(9.87±1.62),the group A(13.69±0.57)and group B(11.22±1.42)had significantly higher levels of MPV(P<0.05),The difference in MPV between group A and B also had a statistical significance(P<0.05).There was no statistically significant difference in platelet count and PDW between group A and B(P>0.05). Conclusion The level of MPV in T2DM patients becomes higher as the PAD progresses.更多还原