【摘要】 目的探讨新诊断T2DM患者脂代谢异常的临床特征及与IR和非酒精性脂肪肝(NAFLD)发病的关系。方法将110例新诊断T2DM患者分为血脂正常(NC)组和血脂异常组(HTG组、HTC组、Mix组),研究血脂异常与BMI、胰岛素、C-P、HbA1c、胰岛素抵抗指数(HOMA-IR)与NAFLD的相关性。结果受试者中合并脂代谢异常率64.50%(71例);合并NAFLD率57.30%(63例)。BMI、FC-P在HTG、Mix组高于NC组,差异有统计学意义(P<0.05)。BMI及TG为发生NAFLD的独立危险因素(P<0.05)。结论高TG和/或NAFLD的存在为个体IR的标志。控制血脂水平及脂肪肝对延缓糖尿病并发症的发生发展与控制血糖同样重要。更多还原

【Abstract】 Objective To explore the clinical characteristics of newly diagnosed T2DM patients with lipometabolic disturbance and their relations with IR and non-alcoholic fatty liver disease(NAFLD).Methods The 110 newly diagnosed T2DM patients were divided into normal blood lipid group(control group) and abnormal blood lipid groups(including hypertriglyceridemia group,high total cholesterol group,and mix group with both HTG and HTC).The relation of the lipometabolic disturbance with BMI,serum insulin,and C-P,HbA1c,HOMA-IR,and the incidence of NAFLD was observed and analyzed by statistical methods.Results Incidence of lipometabolic disturbance and NAFLD in the subjects was 64.50%(71 cases) and 57.30%(63 cases) respectively.The BMI and fasting C-P were significantly higher in both HTG group and mix group than in control group(P<0.05).The incidence of NAFLD was independently correlated with BMI and HTG(P<0.05).Conclusion The HTG and/or NAFLD are markers of IR.The control of blood lipid and NAFLD are as important as the control of blood glucose for postponing the natural development of diabetic complications.更多还原