PUMA基因与血液系统恶性肿瘤研究进展

【摘要】 p53上调凋亡调控因子(PUMA)可通过p53依赖途径和非p53依赖途径诱导多种肿瘤细胞的凋亡,在肿瘤的发生过程及治疗过程中发挥重要作用。PUMA与多种化学药物诱导血液系统恶性肿瘤细胞凋亡过程有关,其表达与血液系统恶性肿瘤的预后及分期密切相关。更多还原

【Abstract】 p53 up-regulated modulator of apoptosis(PUMA)acts as an essential mediator of apoptosis via p53-dependent and p53-independent mechanisms,which may play a prominent role in the generating and therapeutic process of tumors.It is not only related to many chemotherapy inducing various leukemia cells apoptosis but also to prognosis and staging of Leukemia closely.更多还原