Objective: To investigate the effects of exercise and diet intervention on gene expression and protein level of retinol-binding protein 4(RBP4) in adipose tissue of obesity rats. Method: Sixty healthy male Sprague-Dawley rats (60—95g) were assigned in this study, of which rats were randomly selected as normal dietary control group(C, n=10) and fed with normal standard diet. The remaining 50 rats were fed with high-fat diet. Seven weeks later, 24 diet- induced-obesity rats models were established. They were ...