【摘要】 目的:通过建立胶原诱导性关节炎(collagen inducted arthritis,CIA)大鼠模型,评价骨碎补总黄酮在抑制CIA大鼠关节骨破坏方面的作用及机制。方法:利用皮下注射牛Ⅱ型胶原诱导Wistar大鼠发病,建立CIA大鼠模型。将造模成功且炎症分值在2分及以上的大鼠进行随机分组并进行相应治疗,评价骨碎补总黄酮对关节骨破坏情况的作用。结果:治疗12周后,骨碎补总黄酮组、骨碎补总黄酮加1/2依那西普组、依那西普组骨小梁面积百分数及骨小梁数量均明显高于灭菌用水组(P<0.05);骨小梁分离度明显小于灭菌用水组(P<0.05)。结论:骨碎补总黄酮能明显抑制CIA大鼠炎症关节骨破坏,其作用可能与骨小梁数量减少及骨小梁分离度的增大相关。更多还原

【Abstract】 Objective:Through establishing the rat model of CIA to evaluate the effect and mechanism of Rhizoma Drynariae Flavone on bone destruction of CIA rat.Methods:Subcutaneous injection of bovine typeⅡcollagen was used to induce Wistar rats to fall ill,and then established the rat model of CIA.The rats whose inflammation scores reached to two points or above were randomly divided into four groups,and were treated accordingly.The effect of Rhizoma Drynariae Flavone on bone destruction was evaluated.Results:At 12 weeks after treatment,bone trabecular area percentage and bone trabecular number in Rhizoma Drynariae Flavone group,Rhizoma Drynariae Flavone-1 / 2 Etanercept group,Etanercept group was obviously higher than that of sterilization water group(P<0.05);and the trabecular resolving power of these groups was obviously less than that of sterilization water group(P<0.05).Conclusion:Rhizoma Drynariae Flavone can obviously inhibit inflammation of joint bone destruction of CIA rats,the effect may be related with bone trabecular number reduction and trabecular resolving power increasing.更多还原