【摘要】 背景与目的:结直肠癌根治性手术后复发率达30%~40%,肿瘤复发影响患者生存时间。本研究旨在探讨结直肠癌复发时间(time to relapse,TTR)与肿瘤临床病理参数的关系,并进一步分析TTR对复发后生存时间的影响。方法:分析辽宁省肿瘤医院收治的375例结直肠癌患者的临床资料、病理结果及随访数据,比较结直肠癌复发与临床资料和病理类型的相关性,并研究TTR与复发后总体生存时间的关系。结果:TTR与确诊时肿瘤分期以及有无肺、肝脏转移密切相关。短期复发(<2年)与生存时间密切相关,2~5年内复发与5年以上复发的患者,其生存时间差异无统计学意义(P>0.05)。结论:结直肠癌患者术后复发时间与肿瘤分期及有无肺、肝脏转移密切相关,短期复发是预测复发后生存时间的重要指标。更多还原

【Abstract】 Background and purpose:The risk of recurrence for colorectal cancer after curative surgery is up to 30%-40%. We aimed to evaluate the relationship between time to relapse(TTR) of colorectal cancer with clinical pathological parameters and overall survival after recurrence. Methods: We carried out the analysis of clinical data, pathological examination and follow up information of 375 colorectal cancer patients who admitted to Liaoning Cancer Hospital. Patients were categorized into relapse at <2, 2-5 and >5 years following their initial surgery. Results:TTR was associated with the clinical stage at diagnosis and liver or lung metastasis status. Short TTR(<2 years) was positively associated with survival. However, there was no significant difference in survival between patients who relapsed at 5 years or later compared with those who relapsed between 2 and 5 years. Conclusion: TTR within 2 years is an important predictor of shorter survival for colorectal cancer patients who experienced a relapse.更多还原