【摘要】 目的:评价肺表面活性物质(Pulmonary surfactant,PS)对支气管肺发育不良(bronchopulmonary dysplasia,BPD)婴幼儿肺功能的影响。方法:胎龄<32周,出生体重<1 500 g,出院时诊断为BPD的早产儿40例,按有无使用PS分为PS组(20例)和非PS组(20例)。动态监测两组患儿1岁、2岁、3岁时的肺功能情况,主要是潮气呼吸参数中的达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、吸气时间(Ti)、呼气时间(Te)、潮气量(VT)、身高、体重、出院后3年中因呼吸系统疾病再入院次数。结果:1岁时PS组与非PS组的肺功能参数值、身高、体重、均无明显差异(P均>0.05)。2岁及3岁时PS组的各项肺功能参数、身高、体重均优于非PS组,(P均<0.05),差异有统计学意义。出院后3年中因患呼吸系统疾病再入院次数的比较中发现,PS组平均住院(2.63±0.80)次,而非PS组为(4.57±1.22)次,差异有统计学意义(P<0.05)。结论:PS替代治疗可以改善BPD患儿2岁及3岁时的生长发育状况、肺功能状况、并降低BPD患儿再入院次数。更多还原

【Abstract】 Objective:To assess the effect of pulmonary surfactant(PS) on pulmonary function in bronchopulmonary dysplasia(BPD) infants.Methods:Forty preterm infants with BPD were enrolled(gestational age less than thirty-two weeks,weighting less than 1 500 g),and divided into PS and non-PS groups.Pulmonary function was monitored at 1,2,3 years old,including TPTEF/TE,VPEF/VE,Ti,Te,VT.Body height,weight and the times of re-hospitol caused by respiratory disease were detected.Results:At one years old,there were no significant differences between non-PS and PS groups in lung function parameters,height,body weight(P>0.05).At two years old and three years old,all above indicators were better in PS group than those of non-PS group(P<0.05).The number of admited to hospital in PS group was(2.63±0.08) times,however was(4.57±1.22) times in non-PS group,there was significant difference.Conclusion:PS replacement therapy can improve BPD infants of two and three years old the growth condition,pulmonary function,and reduce the number of admissions to hospital.更多还原