【摘要】 目的:观察补充小剂量L-甲状腺素对早产儿暂时性低甲状腺素血症的近期疗效及安全性。方法:将符合条件的63例早产低甲状腺素血症儿分为治疗组32例和对照组31例,治疗组给予小剂量L-甲状腺素片口服,观察两组在静脉营养、光疗、住院时间、恢复出生体重、消化异常、心率及颅内异常发生率等方面差异,比较治疗组在治疗前后血生化方面改变。结果:治疗组静脉营养、光疗、恢复出生体重及住院时间比对照组明显缩短(P<0.05),消化系统异常天数减少(P<0.01),心率无明显增快(P>0.05),颅内出血及脑白质病发生率无增加(P>0.05)。治疗组在治疗前后血谷丙转氨酶、肌酐、尿素氮、前白蛋白、心肌酶及血糖无明显变化(P>0.05)。结论:早期小剂量补充甲状腺素安全有效,可以提高患儿早期生活质量,减少家长经济负担。更多还原

【Abstract】 Objective:To observe the short-term curative effect and safety of supplementary therapy with low dose L-thyroxine for treatment of transient hypothyroxinemia in premature infants.Methods:Sixty-three premature infants with hypothyroxinemia were divided into treatment group(32 premature infants) and control group(31 premature infants);the premature infants in treatment group were treated with oral administration of low dose L-thyroxine pills;the differences of intravenous nutrition time,phototherapy time,hospitalization time,the time to return to birth weight,digestive system abnormalities,heart rate,and the incidence rates of intracranial abnormalities were observed in the two groups;the changes of blood biochemical items in treatment group before and after treatment were compared.Results:The intravenous nutrition time,phototherapy time,hospitalization time,and the time to return to birth weight in treatment group were statistically significantly shorter than those in control group(P<0.05).The duration time of digestive system abnormalities in treatment group was statistically significantly shorter than that in control group(P<0.01).Heart rate and the incidence rates of intracranial hemorrhage and leukoencephalopathy in treatment group didn’t increase significantly(P>0.05).In treatment group,the levels of alanine transaminase,creatinine,urea nitrogen,pre-albumin,myocardial enzyme,and blood glucose after treatment didn’t change obviously(P>0.05).Conclusion:Early supplementation of low dose thyroxine is safe and effective,which can improve the quality of life of premature infants and reduce economic burden of parents.更多还原