【摘要】 目的观察长春瑞滨联合奥沙利铂治疗复发卵巢癌的疗效及不良反应。方法本组22例患者给予长春瑞滨和奥沙利铂治疗,连用2个周期后进行影像学检查、CA125评价疗效和观察不良反应。结果完全缓解(CR)1例(4.54%),部分缓解(PR)8例(36.36%),稳定(SD)9例(40.9%),进展(PD)4例(18.2%),总有效率(CR+PR)40.9%。不良反应主要为血液系统毒性、胃肠道反应和神经系统毒性,但均未影响继续治疗,总体疗效满意。恶心呕吐17例(77.27%),神经毒性、感觉异常13例(59.09%),白细胞下降15例(68.18%);血小板下降11例(50.0%);贫血5例(22.73%),均在Ⅲ度以下。结论长春瑞滨联合奥沙利铂治疗复发性卵巢癌患者疗效确切,毒性反应可以耐受。更多还原

【Abstract】 Objective To research the effectiveness and adverse reaction of vinorelbine and oxaliplatin in relapse ovar ian cancer.Methods A total of 22 patients in the group were treated with vinorelbine and oxaliplatin,after two cycle,they repeated imaging,CA125 and researched effectiveness and adverse reaction.Results The complete remission(CR) rate was 4.54%(1/22),the patial remission rate was 36.36%(8/22),the stable disease rate was 40.9%(9/22),the progressive disease rate was 18.2%(4/22),and the response rate was 40.9%(9/22).The nausea and vomiting incidence was 17 patients(77.27%),neurotoxicity and cacesthesia was 13 patients(59.09%),leucocytopenia was 15 patients(68.18%),thrombocytopenia was 11 patients(50.0%),anemia was 5 patients(22.73%),all below grade Ⅲ.Conclusion Vinorelbine and oxaliplatin treated relapse ovarian cancer had good effeciacy,the tolerance was good.更多还原